{"title":"George Gomori's Contributions to Diabetes Research and the Origins of the <i>Journal of Histochemistry and Cytochemistry</i>.","authors":"Denis G Baskin","doi":"10.1369/00221554241300370","DOIUrl":null,"url":null,"abstract":"<p><p>Over a period of almost 30 years, Gomori was one of the most prolific and productive investigators in the emerging field of enzyme histochemistry and was recognized by his peers as a pioneer in developing methods for the histochemical demonstration of hydrolytic enzyme activity, most notably phosphatases, esterases, and lipases. Gomori also made important contributions to diabetes research by developing histological techniques that reliably stained the insulin-secreting B cell of the pancreatic islets of Langerhans. Gomori's aldehyde fuchsin staining method was standard for pathological and physiological studies on islet B cells in relation to diabetes and obesity until insulin antibodies became widely available for immunohistochemical identification of B cells. Gomori was a founding member of The Histochemical Society in 1950. When the HCS established the <i>Journal of Histochemistry and Cytochemistry</i> in 1953, Gomori served as one of the first Associate Editors. He also served as President of The Histochemical Society.</p>","PeriodicalId":16079,"journal":{"name":"Journal of Histochemistry & Cytochemistry","volume":" ","pages":"221554241300370"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572951/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Histochemistry & Cytochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1369/00221554241300370","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Over a period of almost 30 years, Gomori was one of the most prolific and productive investigators in the emerging field of enzyme histochemistry and was recognized by his peers as a pioneer in developing methods for the histochemical demonstration of hydrolytic enzyme activity, most notably phosphatases, esterases, and lipases. Gomori also made important contributions to diabetes research by developing histological techniques that reliably stained the insulin-secreting B cell of the pancreatic islets of Langerhans. Gomori's aldehyde fuchsin staining method was standard for pathological and physiological studies on islet B cells in relation to diabetes and obesity until insulin antibodies became widely available for immunohistochemical identification of B cells. Gomori was a founding member of The Histochemical Society in 1950. When the HCS established the Journal of Histochemistry and Cytochemistry in 1953, Gomori served as one of the first Associate Editors. He also served as President of The Histochemical Society.
在将近 30 年的时间里,戈莫里是酶组织化学这一新兴领域中最多产、最有成就的研究人员之一,他被同行公认为是开发水解酶(最主要的是磷酸酶、酯酶和脂肪酶)活性组织化学展示方法的先驱。戈莫里还开发了组织学技术,对胰腺朗格汉斯胰岛分泌胰岛素的 B 细胞进行可靠染色,为糖尿病研究做出了重要贡献。在胰岛素抗体广泛用于 B 细胞的免疫组化鉴定之前,Gomori 的醛富欣染色法一直是胰岛 B 细胞与糖尿病和肥胖有关的病理和生理研究的标准方法。Gomori 是 1950 年组织化学学会的创始成员之一。1953 年,组织化学学会创办了《组织化学与细胞化学杂志》,Gomori 是首批副主编之一。他还担任过组织化学学会主席。
期刊介绍:
Journal of Histochemistry & Cytochemistry (JHC) has been a pre-eminent cell biology journal for over 50 years. Published monthly, JHC offers primary research articles, timely reviews, editorials, and perspectives on the structure and function of cells, tissues, and organs, as well as mechanisms of development, differentiation, and disease. JHC also publishes new developments in microscopy and imaging, especially where imaging techniques complement current genetic, molecular and biochemical investigations of cell and tissue function. JHC offers generous space for articles and recognizing the value of images that reveal molecular, cellular and tissue organization, offers free color to all authors.