Diagnostic value of CT liver-to-spleen attenuation ratio in patients with non-alcoholic fatty liver disease and atherosclerotic plaque.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Pakistan Journal of Medical Sciences Pub Date : 2024-11-01 DOI:10.12669/pjms.40.10.10578

Dong Han, Chongan He, Shuang Gu, Dongxuan Zhang, Liyun Xu

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Abstract

Objective: To explore the clinical value of computed tomography (CT) liver-to-spleen (L/S) attenuation ratio in patients with non-alcoholic fatty liver disease (NAFLD) accompanied by atherosclerotic plaque (AP).

Methods: This was a single-center, retrospective, observational study of patients who were diagnosed with NAFLD undergoing CT scans at Beijing Changping Hospital of Chinese Medicine from April 2020 to April 2022. Patients were grouped according to whether they had a diagnosis of AP or not. Healthy individuals without NAFLD undergoing CT scans during the same period were also included as a control group. The patients were matched for gender, age, and BMI in a 1:1:1 ratio. Correlations between the CT L/S attenuation ratio, liver function indicators, and blood lipid levels were assessed in the three groups. The predictive value of the CT L/S attenuation ratio was evaluated using the receiver operating characteristic (ROC) curve and the area under the curve (AUC) analyses.

Results: Eighty-nine cases in each group. The three groups had significant differences in liver function and blood lipid levels (P<0.05). The CT L/S attenuation ratio in the NAFLD+AP and NAFLD groups was lower than that in the control group and was the lowest in the NAFLD+AP group (P<0.05). There was no significant correlation between the CT L/S attenuation ratio and liver function indicators (P>0.05), but it positively correlated with high-density lipoprotein (HDL) and negatively correlated with low-density lipoprotein (LDL), triglycerides (TG), and total cholesterol (TC) (P<0.05). The CT L/S attenuation ratio had a high predictive value for NAFLD patients with AP (AUC=0.859).

Conclusions: The CT L/S attenuation ratio in NAFLD patients with AP is significantly reduced and is closely related to the levels of blood lipid indicators. The CT L/S attenuation ratio has a high predictive value for NAFLD patients with AP.

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CT 肝脾衰减比对非酒精性脂肪肝和动脉粥样硬化斑块患者的诊断价值。

目的探讨计算机断层扫描（CT）肝脾（L/S）衰减比在伴有动脉粥样硬化斑块（AP）的非酒精性脂肪肝（NAFLD）患者中的临床价值：这是一项单中心、回顾性、观察性研究，研究对象为2020年4月至2022年4月期间在北京昌平中医院接受CT扫描的非酒精性脂肪肝患者。根据患者是否确诊为非酒精性脂肪肝进行分组。同期接受 CT 扫描的未患有非酒精性脂肪肝的健康人作为对照组。患者的性别、年龄和体重指数按1:1:1的比例进行匹配。对三组患者的 CT L/S 衰减比值、肝功能指标和血脂水平之间的相关性进行了评估。使用接收器操作特征曲线（ROC）和曲线下面积（AUC）分析评估了 CT L/S 衰减比值的预测价值：每组 89 例。三组患者的肝功能和血脂水平差异显著（PPP>0.05），但与高密度脂蛋白（HDL）呈正相关，与低密度脂蛋白（LDL）、甘油三酯（TG）和总胆固醇（TC）呈负相关（PConclusions.ROC）：非酒精性脂肪肝伴 AP 患者的 CT L/S 衰减比值明显降低，且与血脂指标水平密切相关。CT L/S 衰减比值对非酒精性脂肪肝患者的 AP 具有较高的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.