Contribution of ERCC2 rs13181 (Lys751Gln) and rs1799793 (Asp312Asn) polymorphisms to the risk of bladder cancer in Bangladesh

IF 1.4 4区医学 Q4 GENETICS & HEREDITY Cancer Genetics Pub Date : 2024-11-01 DOI:10.1016/j.cancergen.2024.11.002

Md. Ariful Islam , Saima Mubashshira , Md. Mostafijur Rahman , Yearul Kabir

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Abstract

Background

Human Excision Repair Cross-Complementation Group 2 (ERCC2) proteins play a vital role in the nucleotide excision repair pathway through ATP-dependent helicase activity. Several studies found that polymorphisms in the ERCC2 gene are associated with susceptibility to different cancers, although the outcomes were confusing.

Objective

As a result, in this retrospective study, we investigated the relationship between genetic polymorphisms of the ERCC2 gene at codons 312 (rs1799793) and 751 (rs13181) and bladder cancer susceptibility in Bangladesh, as well as the disease's aggressiveness.

Methods

Genetic polymorphisms of ERCC2 were assayed by the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method with 121 bladder cancer patients and 130 healthy controls.

Results

Patients who had the Gln/Gln polymorphism of ERCC2 at codon 751 (OR=3.27; 95% CI=1.19-8.67; p<0.05) and Asp/Asn at codon 312 (OR=2.14; 95% CI=1.03-4.29; p<0.05) were significantly associated with a higher risk of developing bladder cancer. Again, Gln/Gln polymorphisms in bladder cancer (p<0.05) were more likely to be present in individuals with cancer in the family.

Conclusions

This study reveals that susceptibility and bladder cancer aggressiveness are associated with polymorphisms at codon 751 and Asp/Asn at codon 312 of the ERCC2 gene.

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孟加拉国ERCC2 rs13181（Lys751Gln）和rs1799793（Asp312Asn）多态性对膀胱癌风险的影响。

背景：人类切除修复交叉互补组 2（ERCC2）蛋白通过 ATP 依赖性螺旋酶活性在核苷酸切除修复途径中发挥重要作用。一些研究发现，ERCC2 基因的多态性与不同癌症的易感性有关，但结果却令人困惑：因此，在这项回顾性研究中，我们调查了孟加拉国ERCC2基因312密码子（rs1799793）和751密码子（rs13181）的遗传多态性与膀胱癌易感性以及疾病侵袭性之间的关系：采用基于聚合酶链式反应的限制性片段长度多态性（PCR-RFLP）方法，对121名膀胱癌患者和130名健康对照者进行了ERCC2基因多态性检测：结果：在密码子751处存在ERCC2的Gln/Gln多态性的患者（OR=3.27；95% CI=1.19-8.67；p结论：这项研究表明，膀胱癌的易感性和侵袭性与ERCC2基因751密码子和312密码子的Asp/Asn多态性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genetics ONCOLOGY-GENETICS & HEREDITY

CiteScore

3.20

自引率

5.30%

发文量

167

审稿时长

27 days

期刊介绍： The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. Specific areas of interest include descriptions of new chromosomal, molecular or epigenetic alterations in benign and malignant diseases; novel laboratory approaches for identification and characterization of chromosomal rearrangements or genomic alterations in cancer cells; correlation of genetic changes with pathology and clinical presentation; and the molecular genetics of cancer predisposition. To reach a basic science and clinical multidisciplinary audience, we welcome original full-length articles, reviews, meeting summaries, brief reports, and letters to the editor.