Outcome Analysis of Solitary Extramedullary Plasmacytoma in the Head and Neck: A Clinical Perspective.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-18 DOI:10.1002/hed.27998

Po-Wen Chuang, Wen-Yu Chuang, Ta-Jen Lee, Po-Hung Chang, Yi-Wei Chen, Chia-Hsiang Fu

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Abstract

Introduction: Solitary extramedullary plasmacytomas (SEP) of the head and neck are rare and pose unique challenges. This study aimed to explore the clinical spectrum and treatment outcomes of these neoplasms using multimodal management.

Methods: A retrospective review of 13 patients with SEP of the head and neck. Data on demographics, clinical presentation, diagnostics, treatment, and survival outcomes were analyzed.

Results: One patient refused the treatment and was lost to follow-up. Another one received operation alone. The other 11 patients underwent surgical resection when feasible and showed favorable responses to radiation. Two of them (16.7%) experienced local recurrence, and another two patients (16.7%) progressed to multiple myeloma (MM) within the first 2 years following the initial treatment. Tumor > 2.6 cm significantly affected the post-radiation prognosis.

Conclusion: Although radiotherapy yields favorable immediate outcomes in our limited case series, a subset of cases progresses to MM within the initial 2 years. Despite all tumors being categorized as Stage I, tumor size may still influence prognosis.

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头颈部单发髓外浆细胞瘤的疗效分析：临床视角。

导言：头颈部的单发髓外浆细胞瘤（SEP）非常罕见，并带来了独特的挑战。本研究旨在通过多模式治疗，探索此类肿瘤的临床表现和治疗效果：方法：对13例头颈部SEP患者进行回顾性研究。方法：对13例头颈部SEP患者进行回顾性研究，分析其人口统计学、临床表现、诊断、治疗和生存结果等数据：结果：一名患者拒绝治疗，失去了随访机会。另一位患者仅接受了手术治疗。其他 11 名患者在可行的情况下接受了手术切除，并对放射治疗产生了良好的反应。其中两名患者（16.7%）出现局部复发，另外两名患者（16.7%）在初次治疗后的两年内发展为多发性骨髓瘤（MM）。肿瘤>2.6厘米对放疗后的预后有明显影响：结论：尽管在我们有限的病例系列中，放疗可带来良好的近期疗效，但仍有一部分病例在最初两年内发展为多发性骨髓瘤。尽管所有肿瘤都被归为I期，但肿瘤大小仍可能影响预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.