Pharmacokinetic and Pharmacodynamic Changes in the Older Adults

IF 3.1 4区 医学 Q3 GERIATRICS & GERONTOLOGY Clinics in Geriatric Medicine Pub Date : 2024-11-15 DOI:10.1016/j.cger.2024.03.004
Ettienne Coetzee MBChB, MMed, FCA (SA) , Anthony Ray Absalom MBChB, FRCA, MD (UCT)
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老年人的药代动力学和药效学变化:对麻醉剂的影响。
越来越多的麻醉科医生需要护理体弱的老年患者。详细了解年龄对麻醉药物的药代动力学和动态变化的影响对于实现最佳安全和护理至关重要。对于大多数麻醉药物来说,老年人需要较低的剂量才能达到相同的血浆浓度,而且在任何给定的血浆和效应部位浓度下,他们都会比年轻患者产生更深远的临床影响。因此需要谨慎行事,密切监测临床效果,积极滴定给药剂量,以达到理想的效果水平,最好遵循 "从低开始,慢慢来 "的原则。
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来源期刊
Clinics in Geriatric Medicine
Clinics in Geriatric Medicine 医学-老年医学
CiteScore
7.70
自引率
0.00%
发文量
83
审稿时长
>12 weeks
期刊介绍: Clinics in Geriatric Medicine provides the latest diagnostic and therapeutic information in the field of geriatrics. Published four times a year—in February, May, August, and November—each issue covers a single topic in geriatrics, including cardiovascular disease, common geriatric disorders (such as sarcopenia and frailty), dermatology, emergency care, oncology, patient care, psychiatry, and much more.
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