Versatile biological activities of thiosemicarbazones and their metal complexes

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Structure Pub Date : 2024-10-31 DOI:10.1016/j.molstruc.2024.140511

Syeda Bakhtawar Zahra , Ajmal Khan , Nadeem Ahmed , Maham Rafique , Lamia Fatima , Imtiaz Khan , Javid Hussain , Sana Khalid , Hanan A. Ogaly , Mesaik M. Ahmed , Ahmed Al-Harrasi , Zahid Shafiq

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Abstract

One of the most crucial objectives in medicinal chemistry is the development of innovative and beneficial bioactive compounds with various biological activities. Thiosemicarbazone, which serves as a valuable precursor in synthesizing pharmaceutical compounds also acts as a chelating agent and forms complexes with transition metals. They demonstrate remarkable medicinal properties and seem advantageous in terms of generating less toxic and more potent medications. These complexes possess a broad range of biological activities, including antimicrobial, antiviral, anticancer, and antioxidant, and are used as enzyme inhibitory agents. This review summarizes recent works providing detailed information on the synthesis, characterization, and biological evaluation of several thiosemicarbazones and their metal complexes. Examining various metal complexes with distinct medicinal properties and structural characteristics this review aims to understand the diverse biological potential for therapeutic applications. This work aims to illuminate the potential of these compounds in pioneering innovative treatment modalities across diverse domains by developing knowledge about the structural characteristics that determine their various biological effects. The literature cited in this review covers a comprehensive period of research and development on thiosemicarbazones and their metal complexes, spanning a period of 17 years from 2006 to 2023, reflecting the evolution and current state of research in this field.

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硫代氨基甲酸盐及其金属配合物的多种生物活性

药物化学最重要的目标之一是开发具有各种生物活性的创新型有益生物活性化合物。硫代氨基脲是合成药物化合物的重要前体，也可作为螯合剂与过渡金属形成络合物。它们具有卓越的药用特性，在生成毒性更低、药效更强的药物方面似乎更具优势。这些复合物具有广泛的生物活性，包括抗菌、抗病毒、抗癌和抗氧化，并可用作酶抑制剂。本综述总结了近期的研究成果，详细介绍了几种硫代氨基甲酸盐及其金属配合物的合成、表征和生物学评价。本综述研究了具有不同药用特性和结构特征的各种金属配合物，旨在了解其在治疗应用方面的各种生物潜力。这项工作旨在通过了解决定其各种生物效应的结构特征，阐明这些化合物在不同领域开拓创新治疗模式的潜力。本综述引用的文献涵盖了从 2006 年到 2023 年这 17 年间有关硫代氨基甲酸及其金属复合物的全面研究和开发，反映了该领域研究的演变和现状。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.