Front Cover: Uracil-Selective Cross-Linking in RNA and Inhibition of miRNA Function by 2-Amino-6-vinyl-7-deazapurine Deoxynucleosides (ChemBioChem 21/2024)
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Abstract
MicroRNAs (miRNAs) regulate gene expression through RNA interference. Consequently, miRNA inhibitors, such as anti-miRNA oligonucleotides (AMOs), have attracted attention for treating miRNA overexpression. In article 10.1002/cbic.202400417, Fumi Nagatsugi and co-workers demonstrate that the cross-linkable nucleoside (2-amino-7-deaza-7-propynyl-6-vinylpurine deoxyriboside; dADpVP) reacted to counter uridine with high reactivity upon duplex hybridization. Moreover, the oligonucleotide containing dADpVP targeting the miRNA binding site in mRNA 3′UTR effectively inhibit the miR21 function in cells by covalent formation.
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