Optimized Magnetically Docked Ingestible Capsules for Non-Invasive Refilling of Implantable Devices

IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) Pub Date : 2024-11-17 DOI:10.1002/aisy.202470053

Hind Al-Haddad, Daniele Guarnera, Izadyar Tamadon, Lorenzo Arrico, Giulia Ballardini, Francesco Mariottini, Alessio Cucini, Simone Ricciardi, Fabio Vistoli, Maria Isabella Rotondo, Daniela Campani, Xuyang Ren, Gastone Ciuti, Benjamin Terry, Veronica Iacovacci, Leonardo Ricotti

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Abstract

Magnetically Docked Ingestible Capsules for Non-Invasive Refilling of Implantable Devices

In article number 2400125, Hind Al-Haddad, Leonardo Ricotti, and co-workers advance implanted drug delivery systems with a non-invasive drug-refilling approach. They employ an ISO 13485-compliant ingestible capsule, two magnetic docking units, and a punching system to ensure safe insulin transfer from the capsule to the implanted reservoir. The digestive tract is exploited as an interface, thus enabling controlled and non-invasive refilling of implanted devices. Validation through ex vivo tests on human tissues, bench tests, and a six-week in vivo study on porcine models confirm the system’s safety and efficacy.

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用于植入式设备非侵入性填充的优化磁性对接可吞食胶囊

磁性对接可吸收胶囊用于植入式设备的非侵入性加注在编号为 2400125 的文章中，Hind Al-Haddad、Leonardo Ricotti 及其合作者采用非侵入性药物加注方法推进了植入式给药系统的发展。他们采用了一种符合 ISO 13485 标准的可摄取胶囊、两个磁性对接单元和一个打孔系统，以确保安全地将胰岛素从胶囊转移到植入的储库中。消化道被用作接口，从而实现了植入设备的可控和非侵入式充注。通过对人体组织进行体外测试、工作台测试以及对猪模型进行为期六周的体内研究，证实了该系统的安全性和有效性。

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