{"title":"Catalysis-enabled amine sorting","authors":"Steven J. Malcolmson","doi":"10.1038/s41557-024-01676-w","DOIUrl":null,"url":null,"abstract":"Multicomponent couplings offer powerful approaches for rapidly increasing molecular complexity, but typically require functionally distinct reagents. Now, through dynamic combinatorial chemistry, structurally similar amino groups can be efficiently differentiated, enabling the enantioselective aminomethylamination of dienes to prepare 1,3-diamines.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":null,"pages":null},"PeriodicalIF":19.2000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1038/s41557-024-01676-w","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Multicomponent couplings offer powerful approaches for rapidly increasing molecular complexity, but typically require functionally distinct reagents. Now, through dynamic combinatorial chemistry, structurally similar amino groups can be efficiently differentiated, enabling the enantioselective aminomethylamination of dienes to prepare 1,3-diamines.
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Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry.
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