Association of precuneus Aβ burden with default mode network function.

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-19 DOI:10.1002/alz.14380

Liang Cui, Zhen Zhang, You-Yi Tu, Min Wang, Yi-Hui Guan, Yue-Hua Li, Fang Xie, Qi-Hao Guo

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Abstract

Introduction: It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions.

Methods: Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F-florbetapir positron emission tomography resting-state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated.

Results: In individuals with high PRC Aβ burden, there is a bidirectional relationship between DMN local function or functional connectivity and PRC Aβ deposition across various cognitive states, which is also linked to cognitive function. Even below the PRC Aβ threshold, DMN function remains related to PRC Aβ deposition and cognitive performance.

Discussion: The findings reveal the critical role of PRC Aβ deposition in disrupting neural networks associated with cognitive decline and the necessity of early detection and monitoring of PRC Aβ deposition.

Highlights: Precuneus (PRC) Aβ burden impacts DMN function in different cognitive stages. High PRC Aβ burden is linked to early neural compensation and subsequent dysfunction. Low PRC Aβ burden correlates with neural changes before significant Aβ accumulation. Changes in DMN function and connectivity provide insights into AD progression. Early detection of regional Aβ burden can help monitor the risk of cognitive decline.

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楔前肌 Aβ 负荷与默认模式网络功能的关系

简介：淀粉样蛋白-β（Aβ）在默认模式网络（DMN）关键区域的局部负担是否会影响网络和认知功能仍不清楚：默认模式网络（DMN）关键区域的局部淀粉样蛋白-β（Aβ）负担是否会影响网络和认知功能，目前仍不清楚：参与者包括1002名中国临床前阿尔茨海默病研究队列中的个体，他们接受了18F-氟贝他匹正电子发射断层扫描静息态功能磁共振成像扫描和神经心理学测试。研究结果表明，楔前肌（PRC）Aβ负担、DMN功能和认知功能之间存在相关性：结果：在PRC Aβ负荷较高的个体中，DMN局部功能或功能连接性与PRC Aβ沉积之间在各种认知状态下存在双向关系，而PRC Aβ沉积也与认知功能有关。即使在PRC Aβ阈值以下，DMN功能仍与PRC Aβ沉积和认知表现相关：讨论：研究结果揭示了PRC Aβ沉积在破坏与认知能力下降相关的神经网络中的关键作用，以及早期检测和监测PRC Aβ沉积的必要性：亮点：楔前肌（PRC）Aβ负担影响不同认知阶段的DMN功能。高PRC Aβ负担与早期神经补偿和随后的功能障碍有关。低 PRC Aβ 负担与 Aβ 显著积累之前的神经变化相关。DMN功能和连接性的变化为了解AD的进展提供了线索。早期检测区域Aβ负担有助于监测认知能力下降的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.