Does choline have an effect on Transient Global Amnesia (TGA)?

IF 2.4 4区医学 Q3 NEUROSCIENCES BMC Neuroscience Pub Date : 2024-11-18 DOI:10.1186/s12868-024-00898-5

Sasan Rahmanian, Mahsa Shapouri, Mohammad Keshavarz Mohammadian, Zahra Mahmoudi, Zahra Saeedirad, Khadijeh Abbasi Mobarakeh, Abdolrahman Parhiz, Soheila Shekari, Asma Rajabi Harsini, Neda Valisoltani, Sara Khoshdooz, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh

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Abstract

Background: Choline was frequently reported to have some beneficial effects on memory function. However, the association of dietary choline with different types of amnesia is not well understood. The objective of this study was to examine the association between dietary intake of choline and transient global amnesia (TGA).

Methods: This case-control study was carried out on 258 patients with TGA and 520 participants without amnesia. Data on dietary choline intake was collected using a validated food frequency questionnaire (FFQ). All participants were examined for amnesia by a neurologist according to the Kaplan and Hodges criteria.

Results: There was an inverse association between TGA and dietary choline intake after adjustment for age and gender (OR: 0.98, CI 95% 0.96-0.98, P = 0.03). The association remained significant after additional adjusting for physical activity, body mass index (BMI), occupation, marital status, smoking, and drinking alcohol (OR: 0.98, CI 95% 0.96-0.99, P = 0.04) and after further adjustment for calorie and food groups intake (OR: 0.98, CI 95% 0.96-0.99, P = 0.03).

Conclusion: The results of this study indicated that choline may have beneficial effects against TGA. Further longitudinal studies are warranted.

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胆碱对短暂性全局失忆（TGA）有影响吗？

背景：经常有报道称胆碱对记忆功能有一定的益处。然而，膳食中的胆碱与不同类型健忘症之间的关系还不十分清楚。本研究的目的是探讨膳食中胆碱摄入量与短暂性全球遗忘症（TGA）之间的关系：这项病例对照研究的对象是 258 名 TGA 患者和 520 名无健忘症的参与者。通过有效的食物频率问卷（FFQ）收集了有关饮食中胆碱摄入量的数据。所有参与者均由神经科医生根据卡普兰和霍奇斯标准进行健忘症检查：结果：在对年龄和性别进行调整后，TGA与膳食胆碱摄入量呈反向关系（OR：0.98，CI 95% 0.96-0.98，P = 0.03）。在进一步调整体力活动、体重指数（BMI）、职业、婚姻状况、吸烟和饮酒（OR：0.98，CI 95%0.96-0.99，P = 0.04）以及热量和食物种类摄入量（OR：0.98，CI 95%0.96-0.99，P = 0.03）后，两者之间的关系仍然显著：本研究结果表明，胆碱可能对 TGA 有益。需要进一步开展纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.