Long-term taurine supplementation regulates brain mitochondrial dynamics in mice.

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY Basic & Clinical Pharmacology & Toxicology Pub Date : 2024-11-18 DOI:10.1111/bcpt.14101

Heresh Rezaei, Hong-Wei Wang, Weishun Tian, Jing Zhao, Asma Najibi, Socorro Retana-Márquez, Elahe Rafiei, Ayeh Rowhanirad, Samira Sabouri, Mohammadreza Kiafar, Rahil Fazlinezhad, Amir Mohammad Niknahad, Fatemeh Evazzadeh, Seyedeh Tayebeh Anousheh, Mohammad Mehdi Ommati, Hossein Niknahad, Reza Heidari

{"title":"Long-term taurine supplementation regulates brain mitochondrial dynamics in mice.","authors":"Heresh Rezaei, Hong-Wei Wang, Weishun Tian, Jing Zhao, Asma Najibi, Socorro Retana-Márquez, Elahe Rafiei, Ayeh Rowhanirad, Samira Sabouri, Mohammadreza Kiafar, Rahil Fazlinezhad, Amir Mohammad Niknahad, Fatemeh Evazzadeh, Seyedeh Tayebeh Anousheh, Mohammad Mehdi Ommati, Hossein Niknahad, Reza Heidari","doi":"10.1111/bcpt.14101","DOIUrl":null,"url":null,"abstract":"Background: Taurine (TAU) is the most abundant non-protein amino acid in the central nervous system (CNS). However, the molecular mechanism of TAU in the CNS is still poorly understood. Meanwhile, disruption in mitochondrial dynamics is evident in CNS disorders. This study aimed to investigate the effect of TAU on mitochondrial dynamics.Methods: TAU (0.25, 0.5 and 1% in drinking water) was administered to young mice for six months. Several memory/cognition parameters and indices of anxiety/depression were assessed. Meanwhile, various mitochondrial indices and the expression/activity of genes involved in mitochondrial biogenesis and dynamics (Akt, CREB, NRF1, TFAM, PGC-1α, Mfn1, Mfn2, UCP2, PINK1, OPA1, Drp1 and Fis1) were examined.Results: TAU significantly enhanced memory performance, suppressed anxiety and depression-like behaviour, increased mitochondrial biogenesis/dynamics and improved mitochondrial indices. It should be mentioned that there was no significant difference between different concentrations of TAU in changing most brain mitochondrial dynamic biomarkers in the current study.Conclusions: These findings offer more insights into the molecular mechanism for TAU's action in the CNS. However, there is a need for further research to confirm these effects in humans. Overall, this study suggests the potential application of TAU in various neurological disorders and the need for clinical studies on the effects of this amino acid in the brain.","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic & Clinical Pharmacology & Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/bcpt.14101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Taurine (TAU) is the most abundant non-protein amino acid in the central nervous system (CNS). However, the molecular mechanism of TAU in the CNS is still poorly understood. Meanwhile, disruption in mitochondrial dynamics is evident in CNS disorders. This study aimed to investigate the effect of TAU on mitochondrial dynamics.

Methods: TAU (0.25, 0.5 and 1% in drinking water) was administered to young mice for six months. Several memory/cognition parameters and indices of anxiety/depression were assessed. Meanwhile, various mitochondrial indices and the expression/activity of genes involved in mitochondrial biogenesis and dynamics (Akt, CREB, NRF1, TFAM, PGC-1α, Mfn1, Mfn2, UCP2, PINK1, OPA1, Drp1 and Fis1) were examined.

Results: TAU significantly enhanced memory performance, suppressed anxiety and depression-like behaviour, increased mitochondrial biogenesis/dynamics and improved mitochondrial indices. It should be mentioned that there was no significant difference between different concentrations of TAU in changing most brain mitochondrial dynamic biomarkers in the current study.

Conclusions: These findings offer more insights into the molecular mechanism for TAU's action in the CNS. However, there is a need for further research to confirm these effects in humans. Overall, this study suggests the potential application of TAU in various neurological disorders and the need for clinical studies on the effects of this amino acid in the brain.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

长期补充牛磺酸可调节小鼠大脑线粒体的动态变化。

背景：牛磺酸（TAU）是中枢神经系统（CNS）中含量最高的非蛋白氨基酸。然而，人们对牛磺酸在中枢神经系统中的分子机制仍知之甚少。同时，线粒体动力学的破坏在中枢神经系统疾病中十分明显。本研究旨在探讨TAU对线粒体动力学的影响：方法：给幼年小鼠注射 TAU（0.25%、0.5% 和 1% 的饮用水），为期 6 个月。方法：给幼鼠注射 TAU（在饮用水中分别添加 0.25、0.5 和 1%）6 个月，评估其记忆/认知参数以及焦虑/抑郁指数。同时，还检测了各种线粒体指数以及参与线粒体生物生成和动力学的基因（Akt、CREB、NRF1、TFAM、PGC-1α、Mfn1、Mfn2、UCP2、PINK1、OPA1、Drp1和Fis1）的表达/活性：结果：TAU能明显提高记忆力，抑制焦虑和抑郁行为，增加线粒体生物生成/动力学，改善线粒体指数。值得一提的是，在本研究中，不同浓度的TAU在改变大多数脑线粒体动态生物标志物方面没有明显差异：这些研究结果为TAU在中枢神经系统中发挥作用的分子机制提供了更多见解。然而，还需要进一步的研究来证实这些作用对人体的影响。总之，这项研究表明 TAU 有可能应用于各种神经系统疾病，而且有必要对这种氨基酸在大脑中的作用进行临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Basic & Clinical Pharmacology & Toxicology 医学-毒理学

CiteScore

5.60

自引率

6.50%

发文量

126

审稿时长

1 months

期刊介绍： Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.