Synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives via isocyanide-based multicomponent reactions.

IF 2.2 4区 化学 Q2 CHEMISTRY, ORGANIC Beilstein Journal of Organic Chemistry Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.241
Marzieh Norouzi, Mohammad Taghi Nazeri, Ahmad Shaabani, Behrouz Notash
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Abstract

An efficient and facile synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives was developed through the isocyanide-based multicomponent reaction of isocyanides, gem-diactivated olefins, and cyclic imines such as dibenzoxazepine, dibenzothiazepine, and triazolobenzodiazepine under solvent- and catalyst-free conditions. Purposefully, this approach produced various bioactive scaffolds using environmentally friendly, mild, and simple conditions. Due to their bioactive moieties, these compounds with exclusive fluorescence properties may attract great attention in biomedical applications, clinical diagnostics, and conjugate materials.

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通过基于异氰酸酯的多组分反应合成吡咯融合二苯并氧氮杂卓/二苯并硫氮杂卓/三唑并二氮杂卓衍生物。
在无溶剂和催化剂条件下,通过异氰酸酯、宝石活化烯烃和环状亚胺(如二苯并氧氮杂卓、二苯并硫氮杂卓和三唑并二氮杂卓)的多组分反应,开发了一种高效、简便的吡咯融合二苯并氧氮杂卓/二苯并硫氮杂卓/三唑并二氮杂卓衍生物的合成方法。这种方法采用环保、温和、简单的条件,有目的地生产出了各种生物活性支架。由于其生物活性分子,这些具有独特荧光特性的化合物可能会在生物医学应用、临床诊断和共轭材料方面引起极大关注。
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来源期刊
CiteScore
4.90
自引率
3.70%
发文量
167
审稿时长
1.4 months
期刊介绍: The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.
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