ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis.

IF 3.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Heliyon Pub Date : 2024-10-31 eCollection Date: 2024-11-15 DOI:10.1016/j.heliyon.2024.e40003

Jiawei He, Meili Duan, Haizhou Zhuang

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Abstract

Background: Endothelial cell dysfunction and microcirculatory disturbances play crucial roles in the pathogenesis of sepsis. This systematic review and meta-analysis explored the relationship of the plasma levels of the key endothelial proteins intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) with clinical outcomes in patients with sepsis.

Methods: MEDLINE and EMBASE were searched through November 28, 2023. ICAM1 and VCAM1 levels and patient outcomes were evaluated. The primary outcome was the relationship of sepsis with ICAM1 or VCAM1. The secondary outcomes were the relationships of septic shock and multiple-organ dysfunction syndrome (MODS) with ICAM1 and VCAM1. Variables were compared using standardized mean differences (SMDs) with 95 % confidence intervals (CIs).

Results: Forty-one studies were included. ICAM1 (SMD = 1.12, 95 % CI = 0.67, 1.57; P < 0.00001) and VCAM1 (SMD = 0.65; 95 % CI = 0.17, 1.13; P = 0.008) were associated with sepsis. Similarly, both ICAM1 (SMD = 2.30; 95 % CI = 1.30, 3.31; P < 0.00001) and VCAM1 (SMD = 0.93; 95 % CI = 0.27, 1.59; P = 0.006) were associated with MODS. ICAM1 was associated with septic shock (SMD = 1.93; 95 % CI = 0.55, 3.30; P = 0.006), overall mortality (SMD = -1.18; 95 % CI = -1.76, -0.61; P < 0.0001), and sepsis-related mortality (SMD = -0.64; 95 % CI = -0.88, -0.39; P < 0.00001). VCAM1 was associated with overall mortality (SMD = -0.71; 95 % CI = -1.02, -0.40; P < 0.00001), sepsis-related mortality (SMD = -0.62; 95 % CI = -1.14, -0.10; P = 0.02), and MODS-related mortality (SMD = -0.55; 95 % CI = -0.89, -0.21; P = 0.002).

Conclusion: Elevated plasma ICAM1 and VCAM1 levels could increase the risks of sepsis, septic shock, MODS, and mortality.

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ICAM1 和 VCAM1 与败血症患者的预后有关：系统回顾和荟萃分析。

背景：内皮细胞功能障碍和微循环障碍在脓毒症的发病机制中起着至关重要的作用。本系统综述和荟萃分析探讨了脓毒症患者血浆中关键内皮细胞蛋白细胞间粘附分子1（ICAM1）和血管细胞粘附分子1（VCAM1）的水平与临床结果的关系：方法：检索了截至 2023 年 11 月 28 日的 MEDLINE 和 EMBASE。对 ICAM1 和 VCAM1 水平和患者预后进行了评估。主要结果是脓毒症与 ICAM1 或 VCAM1 的关系。次要结果是脓毒性休克和多器官功能障碍综合征（MODS）与 ICAM1 和 VCAM1 的关系。采用标准化均值差异（SMD）和 95 % 置信区间（CI）对变量进行比较：结果：共纳入 41 项研究。ICAM1（SMD = 1.12，95 % CI = 0.67，1.57；P 结论：血浆 ICAM1 和 VCAM1 升高会导致血浆中的 VCAM1 增加：血浆 ICAM1 和 VCAM1 水平升高会增加脓毒症、脓毒性休克、MODS 和死亡率的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heliyon MULTIDISCIPLINARY SCIENCES-

CiteScore

4.50

自引率

2.50%

发文量

2793

期刊介绍： Heliyon is an all-science, open access journal that is part of the Cell Press family. Any paper reporting scientifically accurate and valuable research, which adheres to accepted ethical and scientific publishing standards, will be considered for publication. Our growing team of dedicated section editors, along with our in-house team, handle your paper and manage the publication process end-to-end, giving your research the editorial support it deserves.