Clinical efficacy of Crinone on pregnancy outcomes in frozen embryo transfer: A retrospective study in the Chinese population.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Medicine Pub Date : 2024-11-15 DOI:10.1097/MD.0000000000040453

Lishuang Xu, Fang Xiong, Jie Chen, Xin Jin, Huiming Zeng, Meiling Weng

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Abstract

Background: The aim of this study was to retrospectively investigate the effect of Crinone vaginal gel on pregnancy outcomes in women undergoing natural cycle (NC) frozen embryo transfer (FET) and to obtain the most suitable population for its routine application.

Methods: The 1613 women who underwent FET in the NC regimen [including the controlled ovulation stimulation protocol for the natural cycle, or the controlled ovulation stimulation protocol for the natural cycle (NC-COS)] from 2017 to 2021 were included. All patients were divided into 2 groups including Control group and Crinone group, which administered with or without Crinone vaginal gel. The key clinical information and between the 2 groups was recorded in detail.

Results: The results indicated that there were no statistical differences in blood β human chorionic gonadotropin (HCG) positive rate, clinical pregnancy, live birth, abortion (spontaneous and induced) and stillbirth between Control group and Crinone group. Moreover, Crinone could prevent spontaneous abortion. The spontaneous abortion rate in the Crinone group was 5.93% while this in control group was 8.32%. In the cohort exposed to Femoston, the preventive result was more significant (0/32 vs 5/15, P = .001). Furthermore, Crinone exhibited a significant protective effect on spontaneous abortion in 1520 patients who received no human menopausal gonadotropin (HMG) treatment.

Conclusion: This study demonstrated that the Crinone could protect women against spontaneous abortion, especially in patients who do not need HMG or in combination with Femoston.

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克立酮对冷冻胚胎移植妊娠结局的临床疗效：一项针对中国人群的回顾性研究。

研究背景本研究旨在回顾性调查克立酮阴道凝胶对自然周期（NC）冷冻胚胎移植（FET）妇女妊娠结局的影响，并获得最适合常规应用该凝胶的人群：纳入2017年至2021年接受NC方案[包括自然周期控制性促排卵方案或自然周期控制性促排卵方案（NC-COS）]FET的1613名女性。所有患者被分为两组，包括对照组和克立酮组，分别使用或不使用克立酮阴道凝胶。详细记录了2组患者的主要临床信息和2组之间的差异：结果表明，对照组与克龄蒙组在血β人绒毛膜促性腺激素（HCG）阳性率、临床妊娠、活产、流产（自然流产和人工流产）和死胎方面均无统计学差异。此外，克立酮还能预防自然流产。克立酮组的自然流产率为 5.93%，而对照组为 8.32%。在接受费莫司通治疗的人群中，预防效果更为显著（0/32 对 5/15，P = .001）。此外，在1520名未接受人类绝经期促性腺激素（HMG）治疗的患者中，克利诺酮对自然流产具有显著的保护作用：这项研究表明，克立酮可保护妇女免受自然流产的影响，尤其是在不需要使用 HMG 或与非莫司通联合使用的患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.