Risk factors for left ventricular remodeling after myocardial infarction: A meta-analysis.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Medicine Pub Date : 2024-11-15 DOI:10.1097/MD.0000000000040496

Baozhu Xu, Wenhui Li, Zhuozhi You, Nan Yang, Lanxiang Lin, Yuefeng Li

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Abstract

Background: This study aimed to assess potential risk factors for left ventricular remodeling (LVR) after acute myocardial infarction (MI).

Methods: We systematically searched PubMed, the Cochrane Library, MEDLINE, Embase, Web of Science databases CNKI Scholar, VIP, and WanFang databases for all relevant epidemiological studies published up to August 1, 2023. Fixed-effects model or random-effects model was employed to pool the study-specific effect sizes and 95% confidence intervals (CIs).

Results: Fifteen studies with a total of 3,093,792 participants were included according to inclusion criteria. Major modifiable risk factors associated with LVR after MI were diabetes (odds ratio [OR] = 2.053, 95% CI: 1.504-2.803), MI site (OR = 2.423, 95% CI: 1.584-3.708), cystatin C (OR = 6.204, 95% CI: 1.830-21.036), B-type natriuretic peptide (OR = 2.280, 95% CI: 1.466-3.546), as well as creatine kinase-myocardial band (OR = 1.013, 95% CI: 0.985-1.042).

Conclusion: The current study provides evidence indicating that diabetes, the site of MI, cystatin C, B-type natriuretic peptide, and creatine kinase-myocardial band are the primary risk factors for LVR after MI. Recognizing and addressing these modifiable risk factors is crucial for the development of effective preventive and treatment strategies.

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心肌梗死后左心室重塑的风险因素：荟萃分析

背景：本研究旨在评估急性心肌梗死（MI）后左室重构（LVR）的潜在风险因素：本研究旨在评估急性心肌梗死（MI）后左室重构（LVR）的潜在风险因素：我们系统检索了PubMed、Cochrane图书馆、MEDLINE、Embase、Web of Science数据库CNKI Scholar、VIP和万方数据库中截至2023年8月1日发表的所有相关流行病学研究。采用固定效应模型或随机效应模型汇总研究的效应大小和95%置信区间（CIs）：根据纳入标准，共纳入了15项研究，共计3,093,792名参与者。与心肌梗死后 LVR 相关的主要可改变风险因素是糖尿病（几率比 [OR] = 2.053，95% CI：1.504-2.803）、心肌梗死部位（OR = 2.423，95% CI：1.584-3.708）、胱抑素 C（OR = 6.204，95% CI：1.830-21.036）、B 型钠尿肽（OR = 2.280，95% CI：1.466-3.546）以及肌酸激酶-心肌带（OR = 1.013，95% CI：0.985-1.042）：本研究提供的证据表明，糖尿病、心肌梗死部位、胱抑素 C、B 型钠尿肽和肌酸激酶心肌带是心肌梗死后 LVR 的主要风险因素。认识并解决这些可改变的风险因素对于制定有效的预防和治疗策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.