Effects of the umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Medicine Pub Date : 2024-11-15 DOI:10.1097/MD.0000000000040490

Zhijian Xiao, Xinying Wang, Cheng Li, Lihua Luo, Wei Li

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Abstract

Background: This study aimed to evaluate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of knee osteoarthritis.

Methods: PubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure and Wanfang databases were searched from inception to March 31, 2024. RevMan 5.3 was used to conduct meta-analyses of the final included studies.

Results: Three randomized controlled studies were conducted. Western Ontario and McMaster Universities Osteoarthritis Index was reduced in the UC-MSCs group compared that in to the control group (mean difference: -25.85; 95% confidence interval: -41.50, -10.20; P = .001). Knee Lysholm Score was improved in the UC-MSCs group compared with the control group (mean difference: 18.33; 95% confidence interval: 12.89, 23.77; P < .00001). Egger test showed P = .583, indicating no publication bias. Sensitivity analysis indicated that the results were stable.

Conclusion: Intra-articular injection of UC-MSCs improved function and reduced pain in patients with knee osteoarthritis. However, the number of included studies was small and more studies are needed to confirm this.

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脐带间充质干细胞治疗膝骨关节炎的效果：系统回顾与荟萃分析。

背景：本研究旨在评估脐带间充质干细胞（UC-MSCs）治疗膝骨关节炎的效果：本研究旨在评估脐带间充质干细胞（UC-MSCs）治疗膝骨关节炎的效果：方法：检索了从开始到2024年3月31日的PubMed、Web of Science、Cochrane Library、Embase、中国国家知识基础设施和万方数据库。使用RevMan 5.3对最终纳入的研究进行荟萃分析：结果：共进行了三项随机对照研究。与对照组相比，UC-间充质干细胞组的西安大略和麦克马斯特大学骨关节炎指数有所下降（平均差异：-25.85；95% 置信区间：-41.50, -10.20；P = .001）。与对照组相比，UC-间充质干细胞组的膝关节莱斯霍尔姆评分（Knee Lysholm Score）有所改善（平均差异：18.33；95% 置信区间：-41.50；P = .001）：平均差异：18.33；95% 置信区间：12.89，23.77；P = 0.001）：膝关节骨性关节炎患者关节内注射 UC-间充质干细胞可改善功能，减轻疼痛。然而，纳入的研究数量较少，需要更多的研究来证实这一点。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.