Importance of Lymph Node Metastasis to the Pancreatic Head Region in Patients with Ampulla of Vater Carcinoma.

IF 0.8 Q4 SURGERY Surgical technology international Pub Date : 2024-11-18

Motoyasu Tabuchi, Shinya Sakamoto, Teppei Tokumaru, Jun Iwata, Manabu Matsumoto, Rika Yoshimatsu, Tatsuo Iiyama, Yasuhiro Shimada, Takehiro Okabayashi

{"title":"Importance of Lymph Node Metastasis to the Pancreatic Head Region in Patients with Ampulla of Vater Carcinoma.","authors":"Motoyasu Tabuchi, Shinya Sakamoto, Teppei Tokumaru, Jun Iwata, Manabu Matsumoto, Rika Yoshimatsu, Tatsuo Iiyama, Yasuhiro Shimada, Takehiro Okabayashi","doi":"","DOIUrl":null,"url":null,"abstract":"Introduction: Owing to their rarity, clinicopathologic variables and postoperative outcomes in patients with ampulla of Vater carcinoma (AVC) have not been fully elucidated.Materials and methods: A retrospective review of the clinical records of patients who underwent surgical exploration for AVC was performed using univariate and multivariate analyses.Results: One-, three-, and five-year overall survival rates after surgery were 97.4%, 71.8%, and 63.0%, respectively. The most frequently observed sites of recurrence were lymph nodes in 11 patients (52%), followed by the liver in eight (38%), lung in six (29%), local in three (14%), and peritoneal dissemination in three (14%). On multivariate analysis, only the presence of lymph node metastasis extending to the pancreatic head region predicted inferior relapse-free survival. A significant correlation between postoperative recurrence and pathological lymph node metastasis was observed.Conclusions: Lymph node metastasis, especially that extends to the pancreatic head region, was clearly identified as a prognostic indicator of reduced relapse-free survival in patients with AVC.","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgical technology international","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Owing to their rarity, clinicopathologic variables and postoperative outcomes in patients with ampulla of Vater carcinoma (AVC) have not been fully elucidated.

Materials and methods: A retrospective review of the clinical records of patients who underwent surgical exploration for AVC was performed using univariate and multivariate analyses.

Results: One-, three-, and five-year overall survival rates after surgery were 97.4%, 71.8%, and 63.0%, respectively. The most frequently observed sites of recurrence were lymph nodes in 11 patients (52%), followed by the liver in eight (38%), lung in six (29%), local in three (14%), and peritoneal dissemination in three (14%). On multivariate analysis, only the presence of lymph node metastasis extending to the pancreatic head region predicted inferior relapse-free survival. A significant correlation between postoperative recurrence and pathological lymph node metastasis was observed.

Conclusions: Lymph node metastasis, especially that extends to the pancreatic head region, was clearly identified as a prognostic indicator of reduced relapse-free survival in patients with AVC.

微信好友朋友圈 QQ好友复制链接

本刊更多论文

淋巴结转移至胰头区对胰腺水肿癌患者的重要性

导言：由于其罕见性，瓦特氏管（ampulla of Vater）癌（AVC）患者的临床病理变量和术后结果尚未完全阐明：采用单变量和多变量分析方法对接受手术切除 AVC 的患者的临床记录进行了回顾性分析：术后一年、三年和五年的总生存率分别为 97.4%、71.8% 和 63.0%。最常观察到的复发部位是淋巴结（11 例，占 52%），其次是肝脏（8 例，占 38%）、肺部（6 例，占 29%）、局部（3 例，占 14%）和腹膜播散（3 例，占 14%）。在多变量分析中，只有淋巴结转移扩展到胰头区域才能预测较低的无复发生存率。术后复发与病理淋巴结转移之间存在明显的相关性：结论：淋巴结转移，尤其是延伸至胰头区域的淋巴结转移，被明确为AVC患者无复发生存率降低的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊