High-Throughput Microfluidic 3D Outer Blood-Retinal Barrier Model in a 96-Well Format: Analysis of Cellular Interactions and Barrier Function in Retinal Health and Disease (Adv. Mater. Technol. 22/2024)

IF 6.4 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Advanced Materials Technologies Pub Date : 2024-11-19 DOI:10.1002/admt.202470100

Jiho Kim, Youngsook Song, Amber L. Jolly, Taeseon Hwang, Suryong Kim, Byungjun Lee, Jinhwan Jang, Dong Hyun Jo, Kyusuk Baek, Tsung-Li Liu, Sanghee Yoo, Noo Li Jeon

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Abstract

High-Throughput Screening

In article number 2400634, Sanghee Yoo, Noo Li Jeon, and co-workers introduce a high-throughput microphysiological platform for modeling the outer blood-retinal barrier (oBRB) in a 96-well format. This system enables comprehensive evaluation of retinal barrier function, including cellular interactions through transepithelial electrical resistance, permeability assays, and confocal imaging, along with gene expression (RNA analysis) and protein secretion studies. It is designed for high-content drug screening, offering valuable insights into retinal diseases such as age-related macular degeneration.

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96 孔格式的高通量微流控三维外层血液-视网膜屏障模型：视网膜健康和疾病中的细胞相互作用和屏障功能分析（材料与工艺学高级研究班，22/2024）

高通量筛选在文章编号 2400634 中，Sanghee Yoo、Noo Li Jeon 及其合作者介绍了一种高通量微物理平台，用于在 96 孔格式中对外部视网膜血屏障 (oBRB) 进行建模。该系统可对视网膜屏障功能进行全面评估，包括通过跨上皮电阻、通透性测定和共聚焦成像进行的细胞相互作用，以及基因表达（RNA 分析）和蛋白质分泌研究。它专为高含量药物筛选而设计，为老年性黄斑变性等视网膜疾病提供了宝贵的见解。

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来源期刊

Advanced Materials Technologies Materials Science-General Materials Science

CiteScore

10.20

自引率

4.40%

发文量

566

期刊介绍： Advanced Materials Technologies Advanced Materials Technologies is the new home for all technology-related materials applications research, with particular focus on advanced device design, fabrication and integration, as well as new technologies based on novel materials. It bridges the gap between fundamental laboratory research and industry.