Senescence Biomarkers and Trajectories of Frailty and Physical Function After Kidney Transplantation

IF 1.9 4区医学 Q2 SURGERY Clinical Transplantation Pub Date : 2024-11-20 DOI:10.1111/ctr.70022

Elizabeth C. Lorenz, Byron H. Smith, Hani M. Wadei, Girish Mour, Cassie C. Kennedy, Carrie A. Schinstock, Walter K. Kremers, Andrea L. Cheville, LaTonya J. Hickson, Elizabeth J. Atkinson, Thomas A. White, Andrew D. Rule, Nathan K. LeBrasseur

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Abstract

Cellular senescence is a biological mechanism of aging and age-related diseases. The aim of this study was to examine whether senescence biomarkers are associated with frailty and physical function trajectories in patients undergoing kidney transplantation (KT). We also discussed the relationship between senescence biomarkers and KT function. In this multicenter study, we prospectively assessed plasma levels of senescence biomarkers, frailty as measured by the Physical Frailty Phenotype, and physical function as measured by the Short Physical Performance Battery prior to KT. Frailty, physical function, and KT function were also measured 1 year after KT. Variable associations were assessed using Cox and relaxed least absolute shrinkage and selection operation regression. The cohort consisted of 197 participants (mean age 53 ± 13 years, 61.4% male, and 80.2% White race). Higher pre-KT levels of macrophage-derived chemokine (MDC/CCL22) and growth differentiation factor-15 (GDF-15) were independently associated with less improvement in frailty and/or physical function during the first year after KT. Higher pre-KT levels tumor necrosis factor receptor superfamily member 6 (FAS) and MMP-9 levels were independently associated with lower KT function one year after KT. Pre-KT cellular senescence may contribute to frailty, physical function, and kidney function trajectories during the first year after KT.

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衰老生物标志物与肾移植后的虚弱和身体功能轨迹

细胞衰老是导致衰老和老年相关疾病的一种生物学机制。本研究旨在探讨衰老生物标志物是否与肾移植（KT）患者的虚弱和身体功能轨迹相关。我们还讨论了衰老生物标志物与 KT 功能之间的关系。在这项多中心研究中，我们前瞻性地评估了肾移植前血浆中的衰老生物标志物水平、以体质虚弱表型（Physical Frailty Phenotype）衡量的虚弱程度以及以短期体能测试（Short Physical Performance Battery）衡量的体能。KT 1 年后，还对虚弱程度、身体功能和 KT 功能进行了测量。使用 Cox 和松弛最小绝对缩减和选择操作回归评估了变量之间的关联。队列由 197 名参与者组成（平均年龄为 53 ± 13 岁，61.4% 为男性，80.2% 为白种人）。KT前水平较高的巨噬细胞衍生趋化因子（MDC/CCL22）和生长分化因子-15（GDF-15）与KT后第一年虚弱和/或身体功能改善较少独立相关。KT前水平较高的肿瘤坏死因子受体超家族成员6（FAS）和MMP-9水平与KT一年后较低的KT功能独立相关。KT前细胞衰老可能会导致KT后第一年内的虚弱、身体功能和肾功能轨迹。

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来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.