Relationship between immune cell traits, circulating inflammatory cytokines, and the risk of incisional hernia after gastric surgery.

IF 2.6 2区医学 Q1 SURGERY Hernia Pub Date : 2024-11-20 DOI:10.1007/s10029-024-03213-7

Hekai Shi, Heng Song, Qian Wu, Ligang Liu, Zhicheng Song, Yan Gu

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Abstract

Purpose: The systemic and local inflammatory response in patients after surgical operation is closely related to the quality of the wound healing. Low-quality wound healing and defects in the suture technique lead to the occurrence of incisional hernia (IH). However, the causal relationship between human circulating inflammatory cytokines, immune cell traits, and the risk of IH remains unclear.

Methods: We used summary data from genome-wide association studies to assess the causal relationship between 91 types of circulating inflammatory factors, 731 types of circulating immune cell traits, and the risk of IH. The outcome dataset was obtained from FinnGen, including 6,336 patients with IH and 232,612 controls. We performed Mendelian Randomization (MR) analysis to identify their causal relationship and immune cell phenotypes upstream of inflammatory factors. Inverse variance weighting is considered to be the main analysis method.

Results: Among the identified cytokines, TNF-related activation-induced cytokine levels were associated with a lower risk of IH (OR: 0.89; 95% CI: 0.82-0.96; P = 0.003). In contrast, interleukin-5 levels were associated with an increased risk of IH (OR: 1.18; 95% CI: 1.06-1.31; P = 0.003). Additionally, a significant causal relationship was found between four immune cell traits and the risk of IH (P < 0.01). Through two-step MR analysis, we determined that interleukin-5 levels mediate the causal relationship between the relative count of CD25hi % CD4 + in Treg cells and the higher risk of IH.

Conclusion: This study found a causal relationship between specific inflammatory cytokines, immune cell traits, and risk of IH. These results can help surgeons predict the risk of IH and take preventive measures.

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免疫细胞特征、循环炎症细胞因子与胃手术后切口疝风险之间的关系。

目的：外科手术后患者全身和局部的炎症反应与伤口愈合的质量密切相关。低质量的伤口愈合和缝合技术的缺陷会导致切口疝（IH）的发生。然而，人类循环炎性细胞因子、免疫细胞特征与 IH 风险之间的因果关系仍不清楚：我们利用全基因组关联研究的汇总数据评估了 91 种循环炎症因子、731 种循环免疫细胞特征与 IH 风险之间的因果关系。结果数据集来自 FinnGen，包括 6,336 名 IH 患者和 232,612 名对照者。我们进行了孟德尔随机化（MR）分析，以确定它们之间的因果关系以及炎症因子上游的免疫细胞表型。逆方差加权被认为是主要的分析方法：在已确定的细胞因子中，与 TNF 相关的活化诱导细胞因子水平与较低的 IH 风险相关（OR：0.89；95% CI：0.82-0.96；P = 0.003）。相比之下，白细胞介素-5水平与IH风险增加相关（OR：1.18；95% CI：1.06-1.31；P = 0.003）。此外，研究还发现四种免疫细胞特质与 IH 风险之间存在明显的因果关系（P 结论：免疫细胞特质与 IH 风险之间存在明显的因果关系：本研究发现了特定炎性细胞因子、免疫细胞特质与 IH 风险之间的因果关系。这些结果有助于外科医生预测 IH 风险并采取预防措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hernia SURGERY-

CiteScore

4.90

自引率

26.10%

发文量

171

审稿时长

4-8 weeks

期刊介绍： Hernia was founded in 1997 by Jean P. Chevrel with the purpose of promoting clinical studies and basic research as they apply to groin hernias and the abdominal wall . Since that time, a true revolution in the field of hernia studies has transformed the field from a ”simple” disease to one that is very specialized. While the majority of surgeries for primary inguinal and abdominal wall hernia are performed in hospitals worldwide, complex situations such as multi recurrences, complications, abdominal wall reconstructions and others are being studied and treated in specialist centers. As a result, major institutions and societies are creating specific parameters and criteria to better address the complexities of hernia surgery. Hernia is a journal written by surgeons who have made abdominal wall surgery their specific field of interest, but we will consider publishing content from any surgeon who wishes to improve the science of this field. The Journal aims to ensure that hernia surgery is safer and easier for surgeons as well as patients, and provides a forum to all surgeons in the exchange of new ideas, results, and important research that is the basis of professional activity.