Biomarkers of systemic treatment response: MR images of intratumoral fat deposition in colorectal liver metastases (CRLM) after chemotherapy.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY International Journal of Colorectal Disease Pub Date : 2024-11-20 DOI:10.1007/s00384-024-04762-0

Irmina Morawska, Katarzyna Pasicz, Andrzej Cieszanowski

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Abstract

Purpose: Colorectal cancer cells containing mobile lipids are said to be an early indicator of chemotherapy effects. The objective of the study was to examine the frequency and clinical relevance of intratumoral fat deposition in colorectal liver metastases (CRLM) post-chemotherapy using dual-echo chemical shift gradient-echo magnetic resonance imaging (MRI).

Methods: A retrospective analysis of 98 patients with CRLM diagnosed between 2017 and 2022 (69 M, mean age 62.87 ± 10.73 years old) who had an MRI after chemotherapy was performed. On dual-echo chemical shift gradient-echo MRI, intratumoral fat deposition of CRLM was evaluated. A signal intensity drop of ≥ 12% in opposed-phase images vs. in-phase images indicated intratumoral fat. After chemotherapy, the presence of fat deposition was correlated with patients' overall survival.

Results: Before and after chemotherapy, 0 (0%) and 29 (29.59%) patients exhibited intratumoral fat. The number of CRLM ranged from 1 to 25 with a median of 3 and a mean size of 32.58 ± 22.95 mm. The groups had statistically different survival times. Overall survival was shorter for patients with intratumoral fat deposition in CRLM (32 months (24-60, 95% CI)) than for patients without fat deposition in CRLM (48 months (36-NA, 95% CI)).

Conclusion: In our group, nearly 30% of CRLM patients exhibited intratumoral fat after chemotherapy. Patients with intratumoral fat deposition in CRLM have a shorter overall survival time. The presence of fat in CRLM correlates with a poor long-term prognosis.

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全身治疗反应的生物标志物：化疗后结直肠肝转移瘤（CRLM）瘤内脂肪沉积的磁共振图像。

目的：据说，含有流动脂质的结直肠癌细胞是化疗效果的早期指标。该研究旨在利用双回波化学位移梯度回波磁共振成像（MRI）检查化疗后结直肠肝转移瘤（CRLM）瘤内脂肪沉积的频率和临床相关性：对2017年至2022年间确诊的98例CRLM患者（69例男性，平均年龄（62.87±10.73）岁）化疗后进行磁共振成像的情况进行回顾性分析。在双回波化学位移梯度回波 MRI 上，对 CRLM 的瘤内脂肪沉积进行了评估。与同相位图像相比，对相位图像的信号强度下降≥12%表明存在瘤内脂肪。化疗后，脂肪沉积的存在与患者的总生存率相关：化疗前后，分别有 0 例（0%）和 29 例（29.59%）患者出现瘤内脂肪。CRLM的数量从1到25不等，中位数为3，平均大小为32.58 ± 22.95 mm。两组患者的存活时间存在统计学差异。有瘤内脂肪沉积的CRLM患者的总生存期（32个月（24-60，95% CI））比没有脂肪沉积的CRLM患者的总生存期（48个月（36-NA，95% CI））要短：在我们的研究小组中，近30%的CRLM患者在化疗后出现瘤内脂肪沉积。有瘤内脂肪沉积的 CRLM 患者总生存期较短。CRLM中脂肪的存在与长期预后不良有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Colorectal Disease 医学-外科

CiteScore

4.90

自引率

3.60%

发文量

206

审稿时长

3-8 weeks

期刊介绍： The International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery aims to publish novel and state-of-the-art papers which deal with the physiology and pathophysiology of diseases involving the entire gastrointestinal tract. In addition to original research articles, the following categories will be included: reviews (usually commissioned but may also be submitted), case reports, letters to the editor, and protocols on clinical studies. The journal offers its readers an interdisciplinary forum for clinical science and molecular research related to gastrointestinal disease.