Physicochemical stability and controlled release of vitamin D₃-loaded emulsions stabilised by whey protein isolate-basil seed gum conjugates.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED Journal of microencapsulation Pub Date : 2024-11-20 DOI:10.1080/02652048.2024.2418615

Farzaneh Kouravand, Fakhri Shahidi, Milad Fathi, Arash Koocheki, Sahar Roshanak

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Abstract

Aim: The present study was conducted to produce a new carrier containing whey protein isolate-basil seed gum (WPI-BSG) conjugate to achieve superior physicochemical stability of emulsions containing vitamin D₃ (Vit-D₃).

Methods: Zeta-potential and particle size analysis, spectrophotometric method, encapsulation efficiency, loading capacity and dialysis bag method were used to examined physicochemical stability and Vit-D₃ release from the emulsions.

Results: The conjugate-stabilised emulsion showed maximum encapsulation efficiency (87.05 ± 3.37% (w/w)) and loading capacity (5.43 ± 0.08% (w/w)) at the Vit-D3 concentration of 200 and 300 mg/kg. This emulsion also demonstrated good physical stability after 30 days of storage with the zeta potential and mean droplet size of -79.60 ± 0.62 mV and 1346.82 ± 5.95 nm, respectively. Additionally, the conjugate-stabilised emulsion had a maximum Vit-D₃ retention (chemical stability) of 72.79 ± 3.58% after a 15-day storage period.

Conclusion: Our findings suggest that the conjugate-stabilised emulsion has a good stabilising capacity as a carrier for hydrophobic compounds such as Vit-D₃.

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用乳清蛋白分离物-巴西杉籽胶共轭物稳定的维生素 D3 负载乳剂的理化稳定性和控释。

目的：本研究旨在生产一种含有乳清蛋白分离物-巴西杉种子胶（WPI-BSG）共轭物的新型载体，以实现含有维生素 D3（Vit-D3）的乳剂的卓越理化稳定性：方法：采用 Zeta 电位和粒度分析法、分光光度法、包封效率、负载能力和透析袋法检测乳剂的理化稳定性和维生素 D3 的释放：共轭稳定乳剂在 Vit-D3 浓度为 200 和 300 毫克/千克时显示出最高的包封效率（87.05 ± 3.37%（重量比））和负载能力（5.43 ± 0.08%（重量比））。这种乳剂在储存 30 天后也表现出良好的物理稳定性，zeta 电位和平均液滴大小分别为 -79.60 ± 0.62 mV 和 1346.82 ± 5.95 nm。此外，共轭稳定乳剂在储存 15 天后，Vit-D3 的最大保留率（化学稳定性）为 72.79 ± 3.58%：我们的研究结果表明，共轭稳定乳液作为疏水性化合物（如 Vit-D3）的载体具有良好的稳定能力。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.