Control energy detects discrepancies in good vs. poor readers' structural-functional coupling during a rhyming task.

Abstract

Neuroimaging studies have identified functional and structural brain circuits that support reading. However, much less is known about how reading-related functional dynamics are constrained by white matter structure. Network control theory proposes that cortical brain dynamics are linearly determined by the white matter connectome, using control energy to evaluate the difficulty of the transition from one cognitive state to another. Here we apply this approach to linking brain dynamics with reading ability and disability in school-age children. A total of 51 children ages 8.25 -14.6 years performed an in-scanner rhyming task in visual and auditory modalities, with orthographic (spelling) and phonological (rhyming) similarity manipulated across trials. White matter structure and fMRI activation were used conjointly to compute the control energy of the reading network in each condition relative to a null fixation state. We then tested differences of control energy across trial types, finding higher control energy during non-word reading than word reading, and during incongruent trials than congruent trials. ROI analyses further showed a dissociation between control energy of the left fusiform and superior temporal gyrus depending on stimulus modality, with higher control energy for visual modalities in fusiform and higher control energy for auditory modalities in STG. Together, this study highlights that control theory can explain variations on cognitive demands in higher-level abilities such as reading, beyond what can be inferred from either functional or structural MRI measures alone.