The role of ¹⁸F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis.

IF 3.3 2区医学 Q2 ONCOLOGY Radiation Oncology Pub Date : 2024-11-19 DOI:10.1186/s13014-024-02507-5

Milad Ghanikolahloo, Hayder Jasim Taher, Ayoob Dinar Abdullah, Mahsa Asadi Anar, Ali Tayebi, Rahil Rahimi, Faranak Olamaeian, Nima Rahimikashkooli, Nima Kargar

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Abstract

Background and aim: The present study aimed to evaluate the use of ¹⁸F-2-[¹⁸F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to the use of MRI (Magnetic Resonance Imaging) alone.

Methods: We searched numerous databases, including PubMed, Scopus, Embase, and Science Direct, using curated keywords. The variance of each study was determined using the binomial distribution, and STATA version 14 was used to analyze the data by performing random-effect models. Additionally, we calculated study heterogeneity using the chi-squared test and I² index and utilized funnel plots and Egger tests to assess publication bias.

Results: The current investigation analyzed 239 patients from six published studies. The pooled estimated sensitivity and specificity of ¹⁸F-FDG PET/MRI was 0.91 (95% CI = 0.90 to 0.92, I² = 100% and P = 0.000) and 0.62 (95% CI = 0.53 to 0.72, I² = 99.8% and P = 0.000), respectively. Pooled sensitivity and specificity of MRI were 0.78 (95%CI = 0.59 to 0.96, I² = 100% and P = 0.000) and 0.56 (95%CI = 0.33 to 0.80, I² = 99.8% and P = 0.000), respectively.

Conclusions: Based on our findings, the combined form of ¹⁸F-FDG PET/MRI imaging is more sensitive and specific than MRI alone for predicting response to NAC in BC patients.

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18F-FDG PET/MRI 在评估乳腺癌患者对新辅助化疗的病理完全反应中的作用：系统综述和荟萃分析。

背景和目的：本研究旨在评估18F-2-[18F]-氟-2-脱氧葡萄糖（FDG）PET/MRI（正电子发射断层扫描-计算机断层扫描）在预测乳腺癌（BC）患者对新辅助化疗（NAC）的病理反应方面的应用，并与单独使用MRI（磁共振成像）进行比较：方法：我们使用已设定的关键词检索了众多数据库，包括 PubMed、Scopus、Embase 和 Science Direct。使用二项分布确定了每项研究的方差，并使用 STATA 14 版通过随机效应模型对数据进行分析。此外，我们还利用卡方检验和I2指数计算了研究的异质性，并利用漏斗图和Egger检验评估了发表偏倚：本次调查分析了六项已发表研究中的 239 名患者。18F-FDG PET/MRI 的集合估计灵敏度和特异性分别为 0.91（95% CI = 0.90 至 0.92，I2 = 100%，P = 0.000）和 0.62（95% CI = 0.53 至 0.72，I2 = 99.8%，P = 0.000）。核磁共振成像的汇总敏感性和特异性分别为0.78（95%CI=0.59至0.96，I2=100%，P=0.000）和0.56（95%CI=0.33至0.80，I2=99.8%，P=0.000）：根据我们的研究结果，在预测 BC 患者对 NAC 的反应方面，18F-FDG PET/MRI 联合成像比单独 MRI 更敏感、更特异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation Oncology ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

6.50

自引率

2.80%

发文量

181

审稿时长

3-6 weeks

期刊介绍： Radiation Oncology encompasses all aspects of research that impacts on the treatment of cancer using radiation. It publishes findings in molecular and cellular radiation biology, radiation physics, radiation technology, and clinical oncology.