Yuru Bai, Hong Chen, Yuanyuan Duanmu, Hang Shi, Huifang Fu, Yanyi Yu
{"title":"Adverse skin reactions secondary to sintilimab for advanced gastric adenocarcinoma: A case report and literature review.","authors":"Yuru Bai, Hong Chen, Yuanyuan Duanmu, Hang Shi, Huifang Fu, Yanyi Yu","doi":"10.3892/mco.2024.2800","DOIUrl":null,"url":null,"abstract":"<p><p>Immune checkpoint inhibitors, a class of anticancer drugs, which act via enhancing T cell responses against tumor cells, are associated with immune-related adverse events. The skin is one of the most commonly affected organs. In the present study, a case of a 78-year-old man, who developed systemic eczema dermatitis due to neoadjuvant treatment of locally advanced gastric adenocarcinoma with sintilimab combined with Tigio plus oxaliplatin regimen, was reported. The eczema dermatitis completely subsided after treatment with methylprednisolone. The patient and his family strongly requested surgical intervention. Postoperative pathology revealed a pathological complete response.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"22 1","pages":"5"},"PeriodicalIF":1.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574701/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3892/mco.2024.2800","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Immune checkpoint inhibitors, a class of anticancer drugs, which act via enhancing T cell responses against tumor cells, are associated with immune-related adverse events. The skin is one of the most commonly affected organs. In the present study, a case of a 78-year-old man, who developed systemic eczema dermatitis due to neoadjuvant treatment of locally advanced gastric adenocarcinoma with sintilimab combined with Tigio plus oxaliplatin regimen, was reported. The eczema dermatitis completely subsided after treatment with methylprednisolone. The patient and his family strongly requested surgical intervention. Postoperative pathology revealed a pathological complete response.
免疫检查点抑制剂是一类通过增强 T 细胞对肿瘤细胞的反应而发挥作用的抗癌药物，但与免疫相关的不良反应也与之相关。皮肤是最常受影响的器官之一。本研究报告了一例 78 岁的男性患者，他在接受辛替利单抗联合替吉奥加奥沙利铂方案的新辅助治疗局部晚期胃腺癌时出现了全身性湿疹皮炎。经甲基强的松龙治疗后，湿疹皮炎完全消退。患者及其家属强烈要求进行手术治疗。术后病理结果显示病理完全反应。
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