Impact of genetic variants on fentanyl metabolism in major breast surgery patients: a candidate gene association study.

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics Pub Date : 2024-11-20 DOI:10.1080/14622416.2024.2429365

Shathish Kumar, Kesavan Ramasamy, Harivenkatesh Natarajan, Shravan Venkatraman, Vishnu Eriyat, Pankaj Kundra

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Abstract

Aim: The study aimed to examine the association of two selected candidate SNPs rs2242480 (CYP3A4) and rs1045642 (ABCB1) with metabolic ratio of plasma norfentanyl to fentanyl concentrations in patients undergoing major breast surgeries.

Methods: The retrospective cross-sectional study was done in 257 female patients. DNA extraction, genotyping of selected SNPs, and drug levels measurement were employed.

Results: A total of 257 female patients were recruited with no loss to follow up. There was no significant association between the two mentioned SNPs and the metabolic ratio (p value > 0.05). As an exploratory analysis, there was a moderately significant negative correlation between metabolic ratio and pupillary constriction to fentanyl (r = -0.27; p < 0.001). There was also a weak but significant positive correlation between metabolic ratio and time for first analgesia in the postoperative period (r = 0.17; p = 0.01).

Conclusion: There was no significant association with the selected candidate SNPs in CYP3A4 and ABCB1 genes and metabolic ratio of norfentanyl to fentanyl in South Indian patients undergoing major breast surgery.

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基因变异对乳腺大手术患者芬太尼代谢的影响：候选基因关联研究。

目的：该研究旨在探讨两个选定的候选 SNPs rs2242480（CYP3A4）和 rs1045642（ABCB1）与接受大型乳腺手术的患者血浆中诺芬太尼和芬太尼浓度的代谢比率之间的关系：对 257 名女性患者进行了回顾性横断面研究。结果：共有 257 名女性患者接受了乳腺大手术：结果：共招募了 257 名女性患者，随访中无一人死亡。上述两个 SNP 与代谢比率之间没有明显关联（P 值大于 0.05）。作为一项探索性分析，代谢比率与芬太尼导致的瞳孔收缩之间存在中等程度的负相关（r = -0.27；p r = 0.17；p = 0.01）：结论：在接受乳房大手术的南印度患者中，CYP3A4和ABCB1基因中的候选SNPs与诺芬太尼和芬太尼的代谢比没有明显关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.