Pediatric Suprasellar Tumors: Unveiling the Mysteries of Craniopharyngioma and Germ Cell Tumors-Insights From Diagnosis to Advanced Therapeutics.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Pediatric neurology Pub Date : 2024-10-28 DOI:10.1016/j.pediatrneurol.2024.10.016

Margaret Shatara, Mohamed S Abdelbaki

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Abstract

Background: Pediatric suprasellar tumors represent a unique and intricate challenge in the landscape of pediatric neuro-oncology.

Methods: We conducted an in-depth literature review, focusing on large clinical trials and major publications in pediatric suprasellar tumors, particularly craniopharyngiomas and germ cell tumors, to provide a comprehensive perspective on the challenges in the diagnosis, treatment, and molecular aspects of these tumors.

Results: Nestled within the critical confines of the suprasellar region, these tumors manifest against the backdrop of crucial growth and developmental processes. The suprasellar region, housing the pituitary gland and surrounding structures, plays a pivotal role in orchestrating hormonal regulation and growth. The emergence of tumors within this delicate terrain introduces a complex array of challenges, encompassing neurological, endocrinological, and developmental dimensions from damage to the hypothalamic-pituitary axis.

Conclusions: This article provides a thorough exploration of pediatric craniopharyngiomas and germ cell tumors, elucidating their clinical presentations, treatment modalities, and outcomes. The focused analysis aims to deepen our understanding of these tumors by offering insights for refined clinical management and improved patient outcomes.

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小儿星上肿瘤：揭开颅咽管瘤和生殖细胞瘤的神秘面纱--从诊断到先进治疗的启示。

背景：小儿鞍上肿瘤是小儿神经肿瘤学领域一个独特而复杂的挑战：小儿鞍上肿瘤是小儿神经肿瘤学领域一个独特而复杂的挑战：我们进行了深入的文献综述，重点关注小儿鞍上肿瘤（尤其是颅咽管瘤和生殖细胞瘤）的大型临床试验和主要出版物，以全面透视这些肿瘤在诊断、治疗和分子方面的挑战：这些肿瘤位于鞍上区域的重要范围内，是在关键的生长和发育过程中出现的。蝶鞍上区是垂体及其周围结构的所在地，在激素调节和生长过程中起着至关重要的作用。下丘脑-垂体轴受到损伤后，在这一微妙区域出现的肿瘤会带来一系列复杂的挑战，包括神经学、内分泌学和发育方面的挑战：本文对小儿颅咽管瘤和生殖细胞瘤进行了深入探讨，阐明了它们的临床表现、治疗方式和结果。重点分析旨在加深我们对这些肿瘤的认识，为完善临床管理和改善患者预后提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.