A Case Involving Linezolid-induced Fatal Lactic Acidosis and Pancytopenia.

Kundan Mehta, Rhea Gandhi, Islahuzzama Salahuddin Ansari, M S Barthwal
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Abstract

We present a case of a 77-year-old female diagnosed with multidrug-resistant (MDR) pulmonary tuberculosis (PTB), on all oral longer regimen [according to Indian Programmatic Management of Drug Resistant Tuberculosis (PMDT) guidelines] for a month. She presented with nausea, vomiting, worsening of breathlessness for a week, pancytopenia, and gradually increasing lactate levels. Various causes of lactic acidosis including metabolic, septic, and hypoxic were ruled out. Despite our dedicated efforts, she tragically passed away due to severe lactic acidosis, a complication associated with linezolid treatment.

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莱奈唑胺诱发致命性乳酸酸中毒和全血细胞减少症的病例
我们报告了一例 77 岁女性患者的病例,她被诊断患有耐多药(MDR)肺结核(PTB),一个月来一直在口服长效治疗方案(根据印度耐药结核病方案管理指南(PMDT))。她出现恶心、呕吐、呼吸困难加重一周、全血细胞减少以及乳酸水平逐渐升高。我们排除了导致乳酸酸中毒的各种原因,包括代谢性、败血症和缺氧。尽管我们竭尽全力,但她还是因利奈唑胺治疗引起的并发症--严重乳酸酸中毒而不幸去世。
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