[Effect of Central Dialysis Fluid Delivery System (CDDS) using high flux dialyzer versus Regular water treatment stations on endotoxemia and inflammatory markers among prevalent patients on Regular Hemodialysis].

Abstract

Purpose: In this study, we compared the effects of a single patient dialysis fluid delivery system (SPDDS) against a continuous dialysis fluid delivery system (CDDS) on inflammatory markers and endotoxemia in a population of patients receiving routine hemodialysis (HD) at Ain Shams University.

Materials and methods: Eighty prevalent HD patients, ages 18 to 60, who were clinically stable and receiving thrice weekly dialysis treatments via an arteriovenous fistula were the subjects of a cross-sectional research. The study excluded patients with double lumen venous catheters used for hemodialysis, acute infections, cancer, and chronic liver disease. Two groups of patients were created by random selection: group I underwent HD using a CDDS water purification system that was implemented at El Demerdash Hospital two years prior, and group II underwent HD using an SPDDS water purification system at Ain Shams University Specialised Hospital.

Results: In both groups, laboratory, inflammatory marker, and demographic data were gathered. Serum samples were taken before and after dialysis to assess the endotoxin levels in each group. Pre-dialysis endotoxin levels were significantly lower in the CDDS group (0.07+/-0.05) compared to the SPDDS group (0.20+/-0.07) with a P value <0.001, and post-dialysis serum endotoxin levels were significantly lower in the CDDS group (0.04+/-0.02) compared to the SDDPS (0.15+/-0.03) with a P value <0.001.

Conclusion: According to our research, the CDDS groups circulating endotoxins had significantly decreased.