Polynucleotide-based treatments for various facial scars including combat injuries.

Michael James Kim, Jovian Wan, Lopatkina Oksana, Lavrik Yuliia, Olena Chugay, Olena Platonova, Olena Sydorchuk, Kyu-Ho Yi
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Abstract

Introduction: This study examines the therapeutic efficacy of polynucleotide-based therapies, specifically REJURAN®, for managing scars and burns. Scars and burns present significant challenges in dermatology, often affecting patients' quality of life. Traditional treatments can be limited in effectiveness, prompting the exploration of innovative approaches like polynucleotide therapy, which utilizes salmon DNA to stimulate tissue repair, modulate inflammation, and enhance collagen production.

Methods: A series of case studies was conducted, including diverse patient profiles with various types of scars and burns. The study evaluated the impact of REJURAN® on scar appearance, texture, and overall skin quality. Some cases also explored the combination of polynucleotide therapy with other treatments such as Platelet-Rich Plasma (PRP) and botulinum toxin.

Results: Notable improvements were observed across cases, including reduced scar visibility and enhanced skin texture. The therapy proved effective in treating post-traumatic, post-operative, and burn-related scars, demonstrating its versatility and potential benefits. Combination therapies showed promising results, though further research is needed.

Conclusion: Polynucleotide-based therapy with REJURAN® shows promise in scar and burn management, offering a novel approach that leverages the body's regenerative processes. Further studies are recommended to confirm these findings and refine treatment protocols.

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基于多核苷酸的各种面部疤痕(包括战伤)治疗方法。
简介:本研究探讨了基于多核苷酸的疗法(特别是 REJURAN®)在治疗疤痕和烧伤方面的疗效。疤痕和烧伤是皮肤科面临的重大挑战,通常会影响患者的生活质量。传统治疗方法的效果可能有限,这促使人们探索创新方法,如利用鲑鱼 DNA 刺激组织修复、调节炎症和促进胶原蛋白生成的多核苷酸疗法:方法:进行了一系列病例研究,包括不同类型的疤痕和烧伤患者。研究评估了 REJURAN® 对疤痕外观、质地和整体皮肤质量的影响。一些病例还探讨了多核苷酸疗法与其他疗法(如富血小板血浆(PRP)和肉毒杆菌毒素)的结合:各病例均有明显改善,包括疤痕减淡和皮肤质地改善。该疗法在治疗创伤后、术后和烧伤相关疤痕方面效果显著,证明了它的多功能性和潜在优势。尽管还需要进一步研究,但联合疗法显示出了良好的效果:基于 REJURAN® 的多核苷酸疗法在疤痕和烧伤治疗方面大有可为,提供了一种利用人体再生过程的新方法。建议开展进一步研究,以证实这些发现并完善治疗方案。
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