Yao-Bin Shen, Xiao-Lin Wang, Qian-Hao Zhuang, Xiao-De An, Bin Qiu, Houchen Wang, Tiesheng Shi, Jian Xiao
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引用次数: 0
Abstract
Water is an ideal green reaction medium in organic synthesis, and the development of water-enabled transformations to synthesize high value-added molecules is particularly attractive but challenging. Herein, we disclosed the water-enabled α-C(sp3)–H amination of 4-dialkylamino-indole-3-carbaldehydes with primary amines for one-step green synthesis of diazepino[6,5,4-cd]indole derivatives. This reaction proceeded via a cascade aldimine condensation/[1,6]-hydride transfer/cyclization sequence, which featured redox-neutral conditions, water as the green reaction medium, simple operation, high atom- and step-economy, and excellent functional group tolerance.
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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