Asymmetric direct Aldol reaction between acetone and aromatic aldehydes catalyzed by diazadioxocalix[2]arene[2]triazine derivatives

Abstract

Novel derivatives of diazadioxocalix[2]arene[2]triazine were synthesized and evaluated for their catalytic effects on direct asymmetric Aldol reactions in organic solvents. Chiral groups were attached to the heteroatom-bridged calix[2]triazine scaffold through reactions involving (R)/(S)-1,2,3,4-tetrahydro-1-naphthylamine with diazadioxocalix[2]arene[2]triazine. Diazadioxocalix[2]arene[2]triazine derivatives were found to be effective catalysts for the reaction of acetone with aromatic aldehydes. According to the obtained results, it has been determined that the moiety of the catalyst affects the configuration of the Aldol product. The Aldol adducts were obtained in excellent yields (93%) and enantioselectivities (96%).