{"title":"DNA Cleavage System by Nanomaterials.","authors":"Jinci Li, Yingcan Zhao","doi":"10.1002/cbic.202400841","DOIUrl":null,"url":null,"abstract":"<p><p>DNA cleavage using specific agents is essential for gaining insights into the mechanisms of DNA breakage, repair, and signal transduction. These cleaving agents hold significant promise as therapeutic drugs in biomedical applications. Recently, the development of biomimetic nanozymes - an innovative class of inorganic nanomaterials that exhibit enzyme-like catalytic activity - has paved the way for the creation of novel DNA cleavage systems. Nanomaterials have been utilized as DNA cleavage agents due to their exceptional catalytic activity and stability. In this review, we summarized the DNA cleavage activities and mechanisms with various nanomaterials. This review study will have great importance on designing the next-generation \"crispr\" nanomaterials for more biomedical and environmental applications.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202400841"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbic.202400841","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
DNA cleavage using specific agents is essential for gaining insights into the mechanisms of DNA breakage, repair, and signal transduction. These cleaving agents hold significant promise as therapeutic drugs in biomedical applications. Recently, the development of biomimetic nanozymes - an innovative class of inorganic nanomaterials that exhibit enzyme-like catalytic activity - has paved the way for the creation of novel DNA cleavage systems. Nanomaterials have been utilized as DNA cleavage agents due to their exceptional catalytic activity and stability. In this review, we summarized the DNA cleavage activities and mechanisms with various nanomaterials. This review study will have great importance on designing the next-generation "crispr" nanomaterials for more biomedical and environmental applications.
要深入了解 DNA 断裂、修复和信号转导的机制，必须使用特定的 DNA 裂解剂。这些裂解剂有望成为生物医学应用中的治疗药物。最近，生物仿生纳米酶--一类具有类似酶催化活性的创新型无机纳米材料--的开发为创建新型 DNA 裂解系统铺平了道路。纳米材料因其卓越的催化活性和稳定性而被用作 DNA 裂解剂。在本综述中，我们总结了各种纳米材料的 DNA 裂解活性和机制。本综述研究将对设计下一代 "crispr "纳米材料具有重要意义，可应用于更多生物医学和环境领域。
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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