Nathan P Wiederhold, Hoja P Patterson, Dora Ferrer, Victor Garcia, George R Thompson, Thomas F Patterson
{"title":"Olorofim demonstrates <i>in vitro</i> activity against <i>Coccidioides</i> species, including isolates against which fluconazole has reduced activity.","authors":"Nathan P Wiederhold, Hoja P Patterson, Dora Ferrer, Victor Garcia, George R Thompson, Thomas F Patterson","doi":"10.1128/aac.00988-24","DOIUrl":null,"url":null,"abstract":"<p><p>We evaluated the <i>in vitro</i> activity of olorofim against <i>Coccidioides</i> species. Olorofim demonstrated potent <i>in vitro</i> activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).</p>","PeriodicalId":8152,"journal":{"name":"Antimicrobial Agents and Chemotherapy","volume":" ","pages":"e0098824"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antimicrobial Agents and Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1128/aac.00988-24","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).
我们评估了 Olorofim 对球孢子菌的体外活性。奥罗菲姆对所有受试分离菌株都表现出了很强的体外活性，其最低抑菌浓度（MIC）范围≤0.008-0.06 µg/mL，几何平均MIC为0.010 µg/mL。对于氟康唑 MIC 值较高（≥16 µg/mL）的分离菌株，包括 MIC 值≥32 µg/mL（奥洛菲 MIC 值范围≤0.008-0.06 µg/mL，几何平均 MIC 值分别为≤0.009 和≤0.013 µg/mL）的菌株，也能保持这种活性。
期刊介绍：
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
