{"title":"Dysregulation of endogenous retroviruses triggers aging and senescence","authors":"Jill A. Kreiling","doi":"10.1038/s43587-024-00759-0","DOIUrl":null,"url":null,"abstract":"A study by Mao, Zhang, Zhuang and colleagues defines a specific class of endogenous retroviruses that are upregulated with age and in cellular senescence by the stress-induced transcription factor ATF3. The expression of endogenous retroviral elements has implications for the development of inflammation that may drive the onset of aging pathologies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1670-1672"},"PeriodicalIF":17.0000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00759-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A study by Mao, Zhang, Zhuang and colleagues defines a specific class of endogenous retroviruses that are upregulated with age and in cellular senescence by the stress-induced transcription factor ATF3. The expression of endogenous retroviral elements has implications for the development of inflammation that may drive the onset of aging pathologies.
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