SnS2 QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Letters Pub Date : 2024-11-22 DOI:10.1021/acs.nanolett.4c04939

Zhenrun Li, Zihui Liang, Peilin Wang, Wenyan Li, Yameng Li, Ning Liu, Qiang Ma

引用次数: 0

Abstract

This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS₂ QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.76 times. Furthermore, the self-assembled surface plasmonic Bi@SiO₂ array was prepared. When the ECL of SnS₂ QDs@MXene resonated with the electronic oscillations in the Bi@SiO₂ NPs array, the luminescence intensity was enhanced and regulated into the directionally polarized signal by the SPC-ECL effect. Remarkably, the detection of CD9-exosomes in saliva was achieved successfully based on the above sensing system, which can be used to analysis the acute exacerbation and chronic persistence of childhood asthma.

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基于SnS2 QDs@MXene欧姆结的表面等离子体耦合ECL传感器检测唾液外泌体以诊断儿童哮喘

本研究提出了一种新型表面等离子体耦合电化学发光（SPC-ECL）方法，用于检测唾液外泌体和诊断儿童哮喘。首先，SnS2 QDs@MXene 欧姆结被开发为高效的 ECL 发射器。欧姆结提供了低电阻，从而降低了接触电阻，提高了电荷注入效率，使 ECL 信号增强了 2.76 倍。此外，还制备了自组装表面等离子体 Bi@SiO2 阵列。当 SnS2 QDs@MXene 的 ECL 与 Bi@SiO2 NPs 阵列中的电子振荡发生共振时，发光强度得到增强，并通过 SPC-ECL 效应调节为定向极化信号。值得注意的是，基于上述传感系统成功实现了唾液中 CD9-外泌体的检测，可用于分析儿童哮喘的急性加重和慢性持续状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.