Jinrui Bai, Bin Li, Dan Qi, Zhuoheng Song, Yue Yao, Chao Liu
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Abstract
Herein, the hydrogen halogenation reaction of diazo compounds with three new halogenating agents under photoinduced conditions is reported. This method realized hydrofluorination, hydrochlorination, and hydrobromination (56 cases in total, with the highest preparative yield of 94%) without requiring heating, transition metal catalysts or photocatalysts and exhibits a broad substrate scope. Notably, gram-scale synthesis using a continuous flow reactor was performed.
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