Impact of individually tailored contrast medium on vascular attenuation in chest CT: a randomized controlled trial.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-11-22 DOI:10.1177/02841851241297531

Mette Karen Henning, Trond Mogens Aaløkken, Anne Catrine Martinsen, Are Hugo Pripp, Safora Johansen

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Abstract

Background: Individually tailored contrast medium (CM) may improve vascular image quality in chest computed tomography (CT).

Purpose: To evaluate vascular attenuation in chest CT by comparing CM dose calculations using lean body mass (LBM) and body surface area (BSA) with a fixed-dose protocol.

Material and methods: Patients referred for contrast-enhanced chest CT were categorized as either normal, muscular, or overweight. Patients were accordingly randomized into three CM dosing protocols: fixed-dose group (n = 87), LBM group (n = 92), and BSA group (n = 93).

Results: Of the patients, 94% in the fixed-dose group, 99% in the LBM group, and 98% in the BSA group achieved optimal vascular attenuation. In the overweight category, lower attenuation was demonstrated in the fixed-dose group compared to the LBM group (P = 0.032) and the BSA group (P = 0.010). In the fixed-dose group, vascular attenuation showed a negative correlation with total body weight for all body composition categories. In the LBM group, a positive correlation was observed between attenuation and total body weight in the muscular category (P = 0.041), while a negative correlation was noted for the overweight category in the BSA group (P = 0.049).

Conclusion: Fixed-dose CM protocol exhibited larger variations in vascular attenuation between patients of various body weights and body compositions compared to tailored CM doses based on LBM and BSA.

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个体定制造影剂对胸部 CT 血管衰减的影响：随机对照试验。

背景：目的：通过比较使用瘦体重（LBM）和体表面积（BSA）计算的造影剂剂量与固定剂量方案，评估胸部 CT 的血管衰减情况：接受造影剂增强胸部 CT 检查的患者被分为正常、肌肉发达或超重。患者被随机分为三种 CM 剂量方案：固定剂量组（87 人）、LBM 组（92 人）和 BSA 组（93 人）：结果：在固定剂量组、LBM 组和 BSA 组的患者中，分别有 94% 、99% 和 98% 达到了最佳血管衰减效果。与 LBM 组（P = 0.032）和 BSA 组（P = 0.010）相比，在超重组中，固定剂量组的衰减较低。在固定剂量组中，在所有身体成分类别中，血管衰减与总重量呈负相关。在 LBM 组中，肌肉发达组的血管衰减与总重量呈正相关（P = 0.041），而在 BSA 组中，超重组的血管衰减与总重量呈负相关（P = 0.049）：结论：与根据 LBM 和 BSA 量身定制的 CM 剂量相比，固定剂量的 CM 方案在不同体重和身体组成的患者之间表现出更大的血管衰减差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta radiologica 医学-核医学

CiteScore

2.70

自引率

0.00%

发文量

170

审稿时长

3-8 weeks

期刊介绍： Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.