Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI:10.1007/s10517-024-06278-7

A A Semendyaev, M A Darenskaya, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, L I Kolesnikova

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Abstract

The activities of NAD- and NADP-dependent isocitrate dehydrogenases (NAD-ICDH and NADP-ICDH), NAD- and NADP-dependent glutamate dehydrogenases (NAD-GDH and NADP-GDH), and NAD- and NADP-dependent malate dehydrogenases (NAD-MDH and NADP-MDH) in ovarian veins lymphocytes in 183 women of reproductive age with pelvic varicose veins (PVV) and 30 women in the control group were determined. The indicators of intracellular enzymatic activity showed multidirectional changes with increasing severity of the disease. Compared to the control group, women with stage II of PVV had higher median values for lactate dehydrogenase (16.69), NAD-GDH (39.48), NADP-GDH (7.48), NADP-MDH (9.06) and lower values of NAD-ICDH (65.41). Women with stage III of PVV had lower median values for succinate dehydrogenase (9.27), NAD-MDH (26.19), and higher values for glucose-6-phosphate dehydrogenase (8.62), lactate dehydrogenase (24.67), NAD-GDH (63.81), NADP-MDH (21.05) compared to the control group. Studying the activity of NAD(P)-dependent dehydrogenases in lymphocytes at the local level during PVV allows us to evaluate the intensity and dynamics of local varicose veins progression, as well as to optimize its correction.

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盆腔静脉曲张妇女卵巢静脉淋巴细胞中 NAD(P)-D 依赖性脱氢酶的活性。

183 名患有盆腔静脉曲张的育龄妇女的卵巢静脉淋巴细胞中 NAD 和 NADP 依赖性异柠檬酸脱氢酶（NAD-ICDH 和 NADP-ICDH）、NAD 和 NADP 依赖性谷氨酸脱氢酶（NAD-GDH 和 NADP-GDH）以及 NAD 和 NADP 依赖性苹果酸脱氢酶（NAD-MDH 和 NADP-MDH）的活性、和 NADP-GDH）、NAD-和 NADP 依赖性谷氨酸脱氢酶（NAD-GDH 和 NADP-GDH）、NAD-和 NADP 依赖性苹果酸脱氢酶（NAD-MDH 和 NADP-MDH）。随着病情的加重，细胞内酶活性指标呈现多向变化。与对照组相比，PVV II 期妇女的乳酸脱氢酶（16.69）、NAD-GDH（39.48）、NADP-GDH（7.48）、NADP-MDH（9.06）的中值较高，而 NAD-ICDH 的中值较低（65.41）。与对照组相比，PVV III 期妇女的琥珀酸脱氢酶（9.27）、NAD-MDH（26.19）的中位值较低，而葡萄糖-6-磷酸脱氢酶（8.62）、乳酸脱氢酶（24.67）、NAD-GDH（63.81）、NADP-MDH（21.05）的中位值较高。通过研究局部静脉曲张期间淋巴细胞中依赖 NAD(P) 的脱氢酶的活性，我们可以评估局部静脉曲张发展的强度和动态，并对其矫正进行优化。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.