Adherence to long-term non-invasive positive airway pressure therapy.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Danish medical journal Pub Date : 2024-10-25 DOI:10.61409/A04240290

Anne Kathrine Staehr-Rye, Tanja Østergaard Irlind, Karen Funderskov, Mona Ring Gätke, Simone Henrietta Lisa Küchen

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Abstract

Introduction: Studies have shown varying patient adherence to long-term non-invasive positive airway pressure therapy (nPAP). We aimed to investigate adherence to long-term nPAP in a Danish cohort of patients with chronic respiratory insufficiency and/or sleep-disordered breathing (SDB) due to neuromuscular disorders (NMD), obesity-hypoventilation syndrome (OHS) or other reasons.

Methods: This cohort study included all adult patients with association to the Respiratory Center East treated with long-term nPAP: bilevel (BiPAP), automatic (APAP) and continuous (CPAP) or adaptive servo-ventilation (ASV) with a remote monitoring system in April 2022. The primary outcome was adherence, defined as a median use of nPAP ≥ 4 hrs/day in April 2022. A preplanned extended subgroup analysis was conducted for patients with data on adherence from initiation and six months onwards.

Results: The primary analysis included 241 patients, of whom 90% were diagnosed with NMD (54%) or OHS (36%). The nPAP was used ≥ 4 hrs/day by 175 patients (73%), including 22 (100%) with ASV, 129 (72%) with BiPAP and 24 (59%) with APAP/CPAP. Treatment adherence was seen in 75% of patients with NMD, 64% with OHS and 84% with other reasons for SDB. The proportion of adherent subjects in the subgroup analysis of 55 patients was relatively stable throughout the six-month period, ranging from 67% to 75% with slight intraindividual variation.

Conclusion: In this retrospective analysis of adults primarily with NMD and OHS, 73% used the prescribed nPAP therapy ≥ 4 hrs/day.

Funding: None TRIAL REGISTRATION.

Clinicaltrials: gov(NCT05379309).

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坚持长期无创气道正压疗法。

导言：研究表明，患者对长期无创气道正压疗法（nPAP）的依从性各不相同。我们的目的是调查丹麦一组因神经肌肉疾病（NMD）、肥胖-过度换气综合征（OHS）或其他原因导致的慢性呼吸功能不全和/或睡眠呼吸障碍（SDB）患者长期坚持 nPAP 治疗的情况：这项队列研究包括 2022 年 4 月在东部呼吸中心接受长期 nPAP 治疗的所有成年患者：双水平 (BiPAP)、自动 (APAP) 和持续 (CPAP) 或带有远程监控系统的自适应伺服通气 (ASV)。主要结果是坚持治疗，即在 2022 年 4 月 nPAP 的中位使用时间≥ 4 小时/天。对从开始使用到 6 个月内有坚持使用数据的患者进行了预先计划的扩展亚组分析：主要分析包括 241 名患者，其中 90% 被诊断为 NMD（54%）或 OHS（36%）。175 名患者（73%）每天使用 nPAP≥ 4 小时，其中 22 人（100%）使用 ASV，129 人（72%）使用 BiPAP，24 人（59%）使用 APAP/CPAP。75% 的 NMD 患者、64% 的 OHS 患者和 84% 的其他 SDB 患者坚持了治疗。在对 55 名患者进行的亚组分析中，坚持治疗的受试者比例在 6 个月期间相对稳定，从 67% 到 75%，个体间略有差异：在这项对主要患有 NMD 和 OHS 的成人进行的回顾性分析中，73% 的患者每天使用规定的 nPAP 治疗≥ 4 小时：无 TRIAL REGISTRATION.Clinicaltrials: gov(NCT05379309).

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.