Skin microbiome dynamics in patients with polymorphic light eruption in response to ultraviolet radiation.

IF 11 1区 医学 Q1 DERMATOLOGY British Journal of Dermatology Pub Date : 2025-03-18 DOI:10.1093/bjd/ljae464
Yacine Amar, Sebastian Niedermeier, Rafaela Silva, Susanne Kublik, Michael Schloter, Tilo Biedermann, Martin Köberle, Bernadette Eberlein
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Abstract

Background: Polymorphic light eruption (PLE) is the most frequent photodermatosis in Europe, with an estimated prevalence of 10-20%, particularly in temperate climates. Itching or burning lesions appear only in sun-exposed areas, predominantly on the chest, arms and forearms, within a few hours following exposure. The cause of the disease remains unknown, yet studies have suggested that microbial elements in the skin may play a role in its pathogenesis.

Objectives: To investigate the skin microbiome of a cohort of patients with PLE upon exposure to ultraviolet radiation (UVR), to assess its role in the onset of PLE lesions.

Methods: Forty-one skin swabs were collected from 11 patients with PLE at baseline and after 3 days of exposure to UVR, and from healthy control participants. The collected swabs were analysed for their microbial composition using a 16S amplicon sequencing approach.

Results: PLE skin showed a dysbalanced microbiome at baseline, with significantly reduced microbial diversity and noticeable colonization by bacterial pathogens, including Staphylococcus aureus. Upon UVR exposure, the PLE microbiome exhibited further loss of diversity and a reduction in beneficial skin commensals. In line with this, we found that UVR exerted strong antimicrobial effects in vitro against representative skin residents.

Conclusions: UVR can lead to profound changes in the skin microbiome, allowing the proliferation of dysbiotic members that can release a variety of elements able to trigger PLE lesions. This is the first study to investigate the cutaneous microbiome changes in patients with PLE upon UVR exposure, offering new insights into disease pathogenesis that has so far been unexplored.

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多形性光糜烂患者皮肤微生物群对紫外线辐射的动态反应。
背景:多形性光糜烂(PLE)是欧洲最常见的光皮肤病,估计发病率为 10%至 20%,尤其是在温带气候地区。瘙痒或灼痛的皮损仅出现在阳光暴露的部位,主要发生在暴露后数小时内的胸部、手臂和前臂。该病的病因尚不清楚,但有研究表明,皮肤微生物元素可能在其发病机制中起作用:目的:我们调查了暴露于紫外线辐射(UVR)时白斑狼疮患者的皮肤微生物组,以评估其在白斑狼疮皮损发病中的作用:方法:从11名白斑狼疮患者的基线皮肤、暴露于紫外线辐射三天后的皮肤以及健康对照组中收集了41个皮肤拭子。采用 16S 扩增子测序法分析所采集拭子的微生物组成:结果:白斑性红斑狼疮患者的皮肤在基线期就已出现微生物组失衡,微生物多样性明显降低,金黄色葡萄球菌等细菌性病原体的定植也很明显。暴露于紫外线后,PLE 微生物群的多样性进一步丧失,有益的皮肤共生菌减少。据此,我们观察到紫外线在体外对具有代表性的皮肤居民产生了强烈的抗菌作用:综上所述,紫外线辐射可导致皮肤微生物群发生深刻变化,使生物机能失调的成员大量繁殖,从而释放出多种可诱发 PLE 病变的元素。这是第一项调查紫外线照射时白斑狼疮患者皮肤微生物组变化的研究,为迄今为止尚未探索的疾病发病机制提供了新的见解。
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来源期刊
British Journal of Dermatology
British Journal of Dermatology 医学-皮肤病学
CiteScore
16.30
自引率
3.90%
发文量
1062
审稿时长
2-4 weeks
期刊介绍: The British Journal of Dermatology (BJD) is committed to publishing the highest quality dermatological research. Through its publications, the journal seeks to advance the understanding, management, and treatment of skin diseases, ultimately aiming to improve patient outcomes.
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