{"title":"Label correlated contrastive learning for medical report generation.","authors":"Xinyao Liu, Junchang Xin, Bingtian Dai, Qi Shen, Zhihong Huang, Zhiqiong Wang","doi":"10.1016/j.cmpb.2024.108482","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>Automatic generation of medical reports reduces both the burden on radiologists and the possibility of errors due to the inexperience of radiologists. The model that utilizes attention mechanism and contrastive learning can generate medical reports by capturing both general and specific semantics. However, existing contrastive learning methods ignore the specificity of medical data, that is, a patient may suffer from multiple diseases at the same time. This means that the lack of fine-grained relationships for contrastive learning will lead to the problem of insufficient specificity.</p><p><strong>Methods: </strong>To address the above problem, a label correlated contrastive learning method is proposed to encourage the model to generate higher-quality reports. Firstly, the refined similarity description matrix of the contrastive relationship between the reports is obtained by calculating the similarities between the multi-label classification of the reports. Secondly, the representations of image features and the embeddings containing semantic information from the decoder are projected into a hidden space. Thirdly, label correlated contrastive learning is performed with the hidden representations of the image, the embeddings of the text, and the similarity matrix. Through contrastive learning, the \"hard\" negative samples that share more labels with the target sample are being assigned more weights. Finally, label correlated contrastive learning and attention mechanism are combined to generate reports.</p><p><strong>Results: </strong>Comprehensive experiments are conducted on widely used datasets, IU X-ray and MIMIC-CXR. Specifically, on IU X-ray dataset, our method achieves METEOR and ROUGE-L scores of 0.198 and 0.392, respectively. On MIMIC-CXR dataset, our method achieves precision, recall, and F-1 scores of 0.384, 0.376, and 0.304, respectively. The results indicate that proposed method outperforms previous state-of-the-art models.</p><p><strong>Conclusions: </strong>This work improves the performance of automatically generating medical reports, making their application in computer-aided diagnosis feasible.</p>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":" ","pages":"108482"},"PeriodicalIF":4.9000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.cmpb.2024.108482","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objective: Automatic generation of medical reports reduces both the burden on radiologists and the possibility of errors due to the inexperience of radiologists. The model that utilizes attention mechanism and contrastive learning can generate medical reports by capturing both general and specific semantics. However, existing contrastive learning methods ignore the specificity of medical data, that is, a patient may suffer from multiple diseases at the same time. This means that the lack of fine-grained relationships for contrastive learning will lead to the problem of insufficient specificity.
Methods: To address the above problem, a label correlated contrastive learning method is proposed to encourage the model to generate higher-quality reports. Firstly, the refined similarity description matrix of the contrastive relationship between the reports is obtained by calculating the similarities between the multi-label classification of the reports. Secondly, the representations of image features and the embeddings containing semantic information from the decoder are projected into a hidden space. Thirdly, label correlated contrastive learning is performed with the hidden representations of the image, the embeddings of the text, and the similarity matrix. Through contrastive learning, the "hard" negative samples that share more labels with the target sample are being assigned more weights. Finally, label correlated contrastive learning and attention mechanism are combined to generate reports.
Results: Comprehensive experiments are conducted on widely used datasets, IU X-ray and MIMIC-CXR. Specifically, on IU X-ray dataset, our method achieves METEOR and ROUGE-L scores of 0.198 and 0.392, respectively. On MIMIC-CXR dataset, our method achieves precision, recall, and F-1 scores of 0.384, 0.376, and 0.304, respectively. The results indicate that proposed method outperforms previous state-of-the-art models.
Conclusions: This work improves the performance of automatically generating medical reports, making their application in computer-aided diagnosis feasible.
期刊介绍:
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.