Rectal colonization with multidrug-resistant organisms and risk for bloodstream infection among high-risk Greek patients.

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2024-11-21 DOI:10.1007/s10096-024-04987-5

Polyxeni Karakosta, Georgios Meletis, Elisavet Kousouli, Efthymia Protonotariou, Aikaterini Tarpatzi, Sophia Vourli, Panagiota Christina Georgiou, Vasiliki Mamali, Lemonia Skoura, Olympia Zarkotou, Spyros Pournaras

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Abstract

Background: Studies link multidrug-resistant organism (MDRO) rectal colonization to increased infection risk, data from Greece, a country with high rates of MDRO, are limited.

Methods: We assessed bloodstream infection (BSI) risk following rectal colonization by MDROs across three Greek hospitals (2019-2022).

Results: Of 4,370 inpatients, 31.1% were colonized by carbapenem-resistant Enterobacterales (CRE), 30.1% carbapenem-resistant Acinetobacter baumannii (CRAB), 5.8% carbapenem-resistant Pseudomonas aeruginosa (CRPA), 28.4% vancomycin-resistant enterococci (VRE). Subsequent BSI from the same MDRO species was developed in 15.6% of CRE, 19.7% of CRAB, 9.2% of CRPA and 3.5% of VRE carriers. Previous rectal colonization increases significantly MDRO BSI risk [RR (95%CI): CRE 5.2 (3.9-6.8), CRAB 2.7 (2.2-3.3), CRPA 9.6 (5.8-16.0), VRE 2.5 (1.5-4.2)].

Conclusion: Clinicians should consider MDRO carriage information for selecting empiric treatment.

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希腊高危患者的耐多药生物直肠定植与血流感染风险。

背景：研究表明，耐多药生物（MDRO）直肠定植与感染风险增加有关：耐多药生物（MDRO）直肠定植与感染风险增加有关的研究，来自MDRO高发国家希腊的数据有限：我们评估了希腊三家医院（2019-2022年）MDRO直肠定植后的血流感染（BSI）风险：在4370名住院患者中，31.1%的患者定植了耐碳青霉烯类肠杆菌（CRE），30.1%的患者定植了耐碳青霉烯类鲍曼不动杆菌（CRAB），5.8%的患者定植了耐碳青霉烯类铜绿假单胞菌（CRPA），28.4%的患者定植了耐万古霉素肠球菌（VRE）。15.6%的CRE、19.7%的CRAB、9.2%的CRPA和3.5%的VRE携带者随后发生了来自同一MDRO菌种的BSI。CRE 5.2 (3.9-6.8)，CRAB 2.7 (2.2-3.3)，CRPA 9.6 (5.8-16.0)，VRE 2.5 (1.5-4.2)]：结论：临床医生在选择经验性治疗时应考虑MDRO携带信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.