Various apolipoprotein E genotypes relate to responsiveness to flaxseed lignan complex in older persons with type 2 diabetes mellitus.

Q3 Medicine Endocrine regulations Pub Date : 2024-11-21 Print Date: 2024-01-01 DOI:10.2478/enr-2024-0026
Douglas E Barre, Kazimiera A Mizier-Barre, Odette Griscti
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Abstract

Objective. The objective of the study was to determine if there would be statistically significant differences or trends among apolipoprotein E genotypes in the responsiveness of members of a cluster of seven measures in older persons with type 2 diabetes mellitus (T2DM) consuming flaxseed lignan complex (FLC). The cluster of seven are abdominal obesity, hypertension, platelet hyperaggregability, hyperglycemia, dyslipidemia (decreased plasma levels of high-density lipoprotein cholesterol (HDLc), and increased plasma levels of triglycerides), increased low-density lipoprotein (LDL) oxidation and increased inflammation. All cluster members exacerbate T2DM. Methods. Sixteen patients with well-controlled T2DM participated in this double-blind randomized, placebo-controlled crossover study consisting of four visits. Apolipoprotein E genotyping was done at visit one. The cluster of seven, diet, exercise, smoking and medication use were assessed at each visit. Results. The 3/4 genotype showed a stronger downward trend in systolic blood pressure compared to the 3/3 genotype with no trend or significant difference in the 2/4 genotype. There was a downward trend in diastolic blood pressure in genotype 3/3 compared genotype 2/4, which showed no significant difference or trend. Only genotype 3/4 showed a significant drop in diastolic pressure compared to genotypes 2/4 and 3/3. HDLc only showed a downward trend in 3/4 relative to genotypes 2/4 and 3/3. LDL apolipoprotein B oxidation (LDL-Box) only showed an upward trend in 3/3 compared to genotypes 2/4 and 3/4. There were no other significant differences or trends by genotype in the cluster of seven. Conclusions. It appears that those with the 2/4 genotype may not benefit from FLC, those with 3/3 and 3/4 genotypes may benefit only in terms of systolic and diastolic pressures, those with the apo E 3/4 genotype should perhaps avoid FLC to manage HDLc, and those with the 3/3 genotype should perhaps avoid FLC to manage LDL apolipoprotein B oxidation.

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各种载脂蛋白 E 基因型与 2 型糖尿病老年人对亚麻籽木酚素复合物的反应有关。
研究目的该研究的目的是确定在服用亚麻籽木酚素复合物(FLC)的 2 型糖尿病(T2DM)老年人中,不同载脂蛋白 E 基因型的人对七项衡量指标中的一组指标的反应性是否存在统计学意义上的显著差异或趋势。这七项指标包括腹部肥胖、高血压、血小板过度聚集、高血糖、血脂异常(血浆中高密度脂蛋白胆固醇(HDLc)水平降低,血浆中甘油三酯水平升高)、低密度脂蛋白(LDL)氧化增加和炎症加剧。所有集群成员都会加重 T2DM。研究方法16 名病情控制良好的 T2DM 患者参加了这项双盲随机、安慰剂对照交叉研究,共进行了四次访视。在第一次就诊时进行载脂蛋白 E 基因分型。在每次就诊时评估七组患者的饮食、运动、吸烟和用药情况。结果显示与 3/3 基因型相比,3/4 基因型的收缩压呈更强的下降趋势,而 2/4 基因型则没有下降趋势或显著差异。与 2/4 基因型相比,3/3 基因型的舒张压呈下降趋势,但无显著差异或趋势。与基因型 2/4 和 3/3 相比,只有基因型 3/4 的舒张压有明显下降。与基因型 2/4 和 3/3 相比,只有基因型 3/4 的高密度脂蛋白胆固醇呈下降趋势。与基因型 2/4 和 3/4 相比,只有 3/3 中的低密度脂蛋白 B 氧化(LDL-Box)呈上升趋势。在七个基因型组中,没有其他明显的差异或趋势。结论。看来,2/4基因型的人可能不会从FLC中获益,3/3和3/4基因型的人可能仅在收缩压和舒张压方面获益,载脂蛋白E 3/4基因型的人或许应避免使用FLC来管理高密度脂蛋白胆固醇,而3/3基因型的人或许应避免使用FLC来管理低密度脂蛋白B氧化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine regulations
Endocrine regulations Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.70
自引率
0.00%
发文量
33
审稿时长
8 weeks
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