Association between weight changes and infective endocarditis in patients with diabetes: A nationwide population-based cohort study.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM International Journal of Obesity Pub Date : 2024-11-21 DOI:10.1038/s41366-024-01687-0
Jung Ho Kim, Se Hee Park, Se Ju Lee, Jinnam Kim, Won Kyung Pyo, Hee-Jung Kim, Jin Young Ahn, Su Jin Jeong, Jun Yong Choi, Joon-Sup Yeom, Kyungdo Han, Nam Su Ku, Seung Hyun Lee
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Abstract

Backgrounds: The association between weight change in patients with diabetes, and the development of infective endocarditis (IE) has never been studied. Therefore, we evaluated the associations of weight changes in patients with diabetes with the development of IE.

Methods: In this Korean population-based cohort study, we included patients with diabetes aged ≥20 years who underwent health screenings twice in a 2-year interval between 2009 and 2012. Patients were categorized into five groups according to the degree of weight change between the two health screenings and were followed up until December 2018. A patient with a weight change of ≤-10% was designated to the severe weight loss group, -10 to ≤-5% to the moderate weight loss group, -5 to ≤5% to the stable weight group, 5 to ≤10% to the moderate weight gain group, and ≥10% to the severe weight gain group. The primary outcome was the incidence of IE.

Results: A total of 1,762,108 patients with diabetes were included. There were 67,580 (3.9%) individuals with severe weight loss, 247,969 (14.1%) with moderate weight loss, 1,267,849 (72.0%) with stable weight, 135,774 (7.7%) with moderate weight gain, 42,936 (2.4%) with severe weight gain. During the follow-up (median, 5.21 years), 828 cases of IE occurred. After adjusting for covariates, both weight loss (HR: 2.41, 95% CI: 1.87-3.12 for the severe weight loss group; HR: 1.28, 95% CI: 1.05-1.55 for the moderate weight loss group) and weight gain (HR: 1.17, 95% CI: 0.91-1.50 for the moderate weight gain group; HR: 1.59, 95% CI: 1.11-2.28 for the severe weight gain group) were associated with an increased risk of IE compared to those for the stable weight group.

Conclusion: Both weight gain and weight loss are associated with an increased incidence of IE, and the greater the degree of weight change, the greater the risk.

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糖尿病患者体重变化与感染性心内膜炎之间的关系:一项全国性人群队列研究。
背景:糖尿病患者的体重变化与感染性心内膜炎(IE)发病之间的关系从未被研究过。因此,我们评估了糖尿病患者体重变化与 IE 发病之间的关系:在这项基于韩国人口的队列研究中,我们纳入了年龄≥20 岁、在 2009 年至 2012 年期间接受过两次健康检查的糖尿病患者。根据两次健康检查之间的体重变化程度将患者分为五组,并随访至2018年12月。体重变化≤-10%的患者被定为重度体重下降组,-10%至≤-5%的患者被定为中度体重下降组,-5%至≤5%的患者被定为稳定体重组,5%至≤10%的患者被定为中度体重增加组,≥10%的患者被定为重度体重增加组。主要结果是IE的发生率:共纳入 1,762,108 名糖尿病患者。67,580人(3.9%)体重严重下降,247,969人(14.1%)体重中度下降,1,267,849人(72.0%)体重稳定,135,774人(7.7%)体重中度增加,42,936人(2.4%)体重严重增加。在随访期间(中位数为 5.21 年),共发生了 828 例 IE。调整协变量后,与体重稳定组相比,体重减轻(体重严重减轻组的 HR:2.41,95% CI:1.87-3.12;体重中度减轻组的 HR:1.28,95% CI:1.05-1.55)和体重增加(体重中度增加组的 HR:1.17,95% CI:0.91-1.50;体重严重增加组的 HR:1.59,95% CI:1.11-2.28)均与 IE 风险增加有关:结论:体重增加和减轻都与 IE 发病率增加有关,体重变化程度越大,风险越高。
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来源期刊
International Journal of Obesity
International Journal of Obesity 医学-内分泌学与代谢
CiteScore
10.00
自引率
2.00%
发文量
221
审稿时长
3 months
期刊介绍: The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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