Global, Regional, and National Prevalence and Disability-Adjusted Life-Years for Female Infertility: Results from a Global Burden of Disease Study, 1990-2019.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY Gynecologic and Obstetric Investigation Pub Date : 2024-11-21 DOI:10.1159/000542408

DongYi Shen, Sen Yang, Cong Qi, Hong Yang

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Abstract

Objectives: We aimed to determine the prevalence of female infertility in 204 countries and territories from 1990 to 2019.

Design: We evaluated the female infertility global burden between 1990 and 2019 in this systematic study.

Materials: The Global Health Data Exchange query tool (http://ghdx.healthdata.org/gbd-results-tool) and sociodemographic index (SDI) (http://ghdx.healthdata.org/data-type/estimate) provided data on the annual prevalence numbers, age-standardized prevalence rates (ASR), and disability-adjusted life-years (DALYs) of female infertility in 204 countries and territories from 1990 to 2019 for various age groups.

Setting: Female infertility has a devastating impact on the physical and mental health of individuals and national fertility. However, most of the previous studies on this subject were conducted on rather small sample sizes and have certain limitations.

Methods: We examined female infertility in terms of prevalence, ASR, and DALYs across different age groups in 204 countries and territories from 1990 to 2019 using data from the Global Health Data Exchange query tool.

Results: From 1990 to 2019, ASR and DALYs for female infertility increased globally. At the SDI quintile level, middle-SDI and high-middle-SDI countries exhibited a faster increase in the ASR of female infertility. In 2019, with the highest female infertility rate recorded among those between the ages of 30-34 years and the lowest among those between the ages of 45-49 years. In 2019, high-income North America recorded the highest proportion of primary infertility, while East Asia recorded the lowest proportion.

Limitations: First, the global burden of disease (GBD) database lacks data for some countries and regions. Second, data access and quality differ across locations. Third, the causes of infertility are not comprehensive, and data on Klinefelter in GBD 2019 in relation to primary infertility were absent.

Conclusion: Globally, the prevalence of DALYs and age-standardized female infertility rates increased from 1990 to 2019.

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全球、地区和国家女性不孕症患病率和残疾调整寿命年数：1990-2019年全球疾病负担研究结果。

引言女性不孕症对个人的身心健康和国家的生育能力都会造成毁灭性的影响。然而，以往关于这一主题的大多数研究都是在样本量相当小的情况下进行的，具有一定的局限性。因此，我们旨在确定 1990 年至 2019 年期间 204 个国家和地区的女性不孕症发病率：我们利用全球健康数据交换查询工具提供的数据，研究了 1990 年至 2019 年期间 204 个国家和地区不同年龄组女性不孕症的患病率、年龄标准化患病率（ASR）和残疾调整生命年（DALYs）：从 1990 年到 2019 年，全球女性不孕症的 ASR 和 DALYs 均有所增加。在社会人口指数（SDI）五分位水平上，中SDI和中高SDI国家的女性不孕症ASR增长较快。2019年，30-34岁年龄段的女性不孕率最高，45-49岁年龄段的女性不孕率最低。2019年，高收入的北美地区原发性不孕症比例最高，而东亚地区比例最低：首先，GBD数据库缺少一些国家和地区的数据。第二，各地数据的获取途径和质量不同。第三，不孕症病因不全面，GBD2019 中与原发性不孕症相关的 Klinefelter 数据为 0：从 1990 年到 2019 年，全球残疾调整寿命年数和年龄标准化女性不孕症患病率均有所上升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic and Obstetric Investigation 医学-妇产科学

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.