Alteration of ceruloplasmin in patients with malaria: a systematic review and meta-analysis of observational studies.

IF 2.4 3区医学 Q3 INFECTIOUS DISEASES Malaria Journal Pub Date : 2024-11-21 DOI:10.1186/s12936-024-05156-x

Kwuntida Uthaisar Kotepui, Aongart Mahittikorn, Polrat Wilairatana, Frederick Ramirez Masangkay, Manas Kotepui

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Abstract

Background: The evidences of oxidative stress-related Plasmodium infection may alter the ceruloplasmin levels were inconsistent. This systematic review and meta-analysis aimed to collate and synthesize literatures on malaria and ceruloplasmin concentrations.

Methods: The systematic review has been registered with PROSPERO (CRD42023454859). Six electronic databases were systematically searched for investigated ceruloplasmin levels in malaria: ProQuest, EMBASE, MEDLINE, Ovid, PubMed, and Scopus, from their inception to August 2023. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for cross-sectional, cohort, and case-control studies. Qualitative synthesis was undertaken to summarize findings from the included studies. For quantitative synthesis, a meta-analysis was performed using random-effects models.

Results: A total of 411 articles were retrieved, and nine studies were included in the review. The majority of included studies found significantly increased ceruloplasmin levels in malaria patients compared to uninfected controls. The meta-analysis showed a significant increase of ceruloplasmin in patients with malaria as compared to uninfected controls (P < 0.01, Hedge's g 1.18, 95% CI 0.90-1.47, I² 59.19%, eight studies).

Conclusion: The systematic review and meta-analysis consistently revealed a significant rise in ceruloplasmin levels among malaria patients. Further research is essential to understand the variations in ceruloplasmin levels between different Plasmodium species and the severity of malaria in patients.

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疟疾患者体内脑磷脂酶的变化：观察性研究的系统回顾和荟萃分析。

背景：与氧化应激相关的疟原虫感染可能改变脑磷脂浓度的证据并不一致。本系统综述和荟萃分析旨在整理和归纳有关疟疾和脑磷脂浓度的文献：该系统综述已在 PROSPERO（CRD42023454859）上注册。系统检索了从开始到 2023 年 8 月调查疟疾中脑磷脂浓度的六个电子数据库：ProQuest、EMBASE、MEDLINE、Ovid、PubMed 和 Scopus。采用乔安娜-布里格斯研究所（Joanna Briggs Institute，JBI）的关键评估工具对横断面研究、队列研究和病例对照研究进行了质量评估。对纳入的研究结果进行了定性综合。在定量综合方面，采用随机效应模型进行了荟萃分析：共检索到 411 篇文章，9 项研究被纳入综述。纳入的大多数研究发现，与未感染的对照组相比，疟疾患者的脑磷脂水平明显升高。荟萃分析表明，与未感染的对照组相比，疟疾患者的脑磷脂明显增加（P 2 59.19%，8 项研究）：系统综述和荟萃分析一致显示，疟疾患者的脑磷脂水平明显升高。进一步的研究对于了解不同疟原虫种类之间脑磷脂水平的变化以及疟疾患者病情的严重程度至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaria Journal 医学-寄生虫学

CiteScore

5.10

自引率

23.30%

发文量

334

审稿时长

2-4 weeks

期刊介绍： Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field.