Christian Carrier, David Meltzer, Micah T Prochaska
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Abstract
Background and objectives: Anaemia is a treatable common condition with various aetiologies and is prevalent in hospitalized patients. However, anaemia is inconsistently worked up and treated in the inpatient setting, in part because there is no standardized inpatient diagnostic and treatment approach to anaemia. Therefore, the objective of this study was to examine the diagnostic approach and prevalence of common aetiologies of anaemia in hospitalized patients and test for an association between aetiologies of anaemia and patient characteristics.
Materials and methods: This study is a prospective observational study of hospitalized adult patients with anaemia. Patient laboratory data were used to assess the frequency of anaemia diagnostic workup and common aetiologies of anaemia.
Results: In a sample of 945 patients (mean age 58 years, 57% female and 72% Black), 30% patients had chronic anaemia, 11% had multifactorial anaemia, 5% had iron deficiency and 37% had insufficient laboratory data to determine their anaemia aetiology (unidentified aetiology). Patients with an unidentified aetiology received fewer transfusions and were more likely to be White, have longer hospital stays and have higher nadir haemoglobin levels.
Conclusion: A significant portion of hospitalized patients with anaemia did not have an identified aetiology. A standardized diagnostic algorithm could decrease this number and help patients receive appropriate treatment.
期刊介绍：
Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections:
1) Transfusion - Transmitted Disease and its Prevention:
Identification and epidemiology of infectious agents transmissible by blood;
Bacterial contamination of blood components;
Donor recruitment and selection methods;
Pathogen inactivation.
2) Blood Component Collection and Production:
Blood collection methods and devices (including apheresis);
Plasma fractionation techniques and plasma derivatives;
Preparation of labile blood components;
Inventory management;
Hematopoietic progenitor cell collection and storage;
Collection and storage of tissues;
Quality management and good manufacturing practice;
Automation and information technology.
3) Transfusion Medicine and New Therapies:
Transfusion thresholds and audits;
Haemovigilance;
Clinical trials regarding appropriate haemotherapy;
Non-infectious adverse affects of transfusion;
Therapeutic apheresis;
Support of transplant patients;
Gene therapy and immunotherapy.
4) Immunohaematology and Immunogenetics:
Autoimmunity in haematology;
Alloimmunity of blood;
Pre-transfusion testing;
Immunodiagnostics;
Immunobiology;
Complement in immunohaematology;
Blood typing reagents;
Genetic markers of blood cells and serum proteins: polymorphisms and function;
Genetic markers and disease;
Parentage testing and forensic immunohaematology.
5) Cellular Therapy:
Cell-based therapies;
Stem cell sources;
Stem cell processing and storage;
Stem cell products;
Stem cell plasticity;
Regenerative medicine with cells;
Cellular immunotherapy;
Molecular therapy;
Gene therapy.
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