Diabetes Microvascular Complications Are Associated with a Reduction in Gait Speed in High-Functioning Older Adults for Outpatient Clinics.

Abstract

Although the association of type 2 diabetes (T2D) with an increased risk of poor physical function and frailty in older adults is widely documented, the underlying pathophysiological pathways linking these two entities are not fully understood. Accordingly, we conducted a cross-sectional observational study aiming to investigate the association of T2D and its microvascular complications retinopathy, nephropathy, and neuropathy, with gait speed (GS), a common surrogate marker of functional decline, adjusting for age, sex, and cognitive function, in the cohort of older adults of the DIALCAT project (Catalonia, Spain). From the initial 335 participants, 84 were excluded because of missing or incorrect GS assessment. The remaining 251 individuals showed a mean (SD) age of 76.5 (5.8) years, of which 50.4% were women, and 69.4% had T2D. Participants were functionally independent (Barthel Index = 95.9 ± 7.3) but showed low physical performance (GS = 0.7 ± 0.3 m/s). Univariate analysis revealed a significant association between GS and sex, body mass index, Barthel index, Mini Mental State Examination (MMSE), Geriatric Depression Scale (GDS) scores, retinopathy, and nephropathy, and a non-significant association between GS and presence/absence of T2D. In multivariate analysis, T2D complications was independently associated with slower GS (β=-0.12 (-0.23, -0.01), p=0.029, with absence of T2D as reference group; and -0.13; (-0.23, -0.04); p=0.007, with T2D without complications as reference group). Further adjustment for MMSE and GDS, which remained significantly associated with GS, attenuated the association of GS with T2D complications. In conclusion, the presence of diabetes complications, encompassing renal, visual, peripheral, and potentially central nervous system levels, was associated with a reduction in gait speed, a relevant marker of physical function and frailty.